Ikeda Tsuyoshi
   Department   SOJO UNIVERSITY  Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES
     /(DC)Division of Pharmaceutical Sciences,
Language English
Publication Date 2010/07
Peer Review Peer reviewed
Title Onionin A from Allium cepa inhibits macrophage activation.
Contribution Type
Journal Journal of natural products
Journal TypeAnother Country
Volume, Issue, Page 73(7),pp.1306-8
Author and coauthor El-Aasr Mona, Fujiwara Yukio, Takeya Motohiro, Ikeda Tsuyoshi, Tsukamoto Sachiko, Ono Masateru, Nakano Daisuke, Okawa Masafumi, Kinjo Junei, Yoshimitsu Hitoshi, Nohara Toshihiro
Details Onionin A (1), a new, stable, sulfur-containing compound, was isolated from acetone extracts of bulbs of onion (Allium cepa), and its structure was characterized as 3,4-dimethyl-5-(1E-propenyl)-tetrahydrothiophen-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis. This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages.
DOI 10.1021/np100105u
ISSN 1520-6025
PMID 20597533