イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2010/06
形態種別 原著論文
査読 査読有り
標題 Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor.
執筆形態 共著
掲載誌名 Bioorganic & medicinal chemistry letters
掲載区分国外
巻・号・頁 20(11),pp.3341-3
著者・共著者 Tsukamoto Sachiko, Yamanokuchi Rumi, Yoshitomi Makiko, Sato Kohei, Ikeda Tsuyoshi, Rotinsulu Henki, Mangindaan Remy E P, de Voogd Nicole J, van Soest Rob W M, Yokosawa Hideyoshi
概要 Aaptamine (1), isoaaptamine (2), and demethylaaptamine (3) were isolated from the marine sponge Aaptossuberitoides collected in Indonesia as inhibitors of the proteasome. They inhibited the chymotrypsin-like and caspase-like activities of the proteasome with IC(50) values of 1.6-4.6 microg/mL, while they showed less inhibition of the trypsin-like activity of the proteasome. The three compounds showed cytotoxic activities against HeLa cells, but their cytotoxicity did not correlate with their potency as proteasome inhibitors, strongly suggesting that their proteasomal inhibitory activity is dispensable to their cytotoxicity.
DOI 10.1016/j.bmcl.2010.04.029
ISSN 1464-3405
PMID 20451377