イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 日本語
発行・発表の年月 2010/05
形態種別 総説
査読 査読有り
標題 [Fascination with natural glycosides].
執筆形態 共著
掲載誌名 Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
掲載区分国内
巻・号・頁 130(5),679-86頁
著者・共著者 Ikeda Tsuyoshi, Miyashita Hiroyuki, Nakano Daisuke, Nohara Toshihiro
概要 Glycosides are a group of compounds known to be the active principle of a natural drug. We have isolated triterpene glycosides from a Leguminosae plant, which improved liver disorder, and steroid glycosides from a plant of the Solanaceous with cytotoxic activity against human cancer cell lines. A biological activity test suggested an important role of the aglycone part and the sugar chain part of those glycosides. Although many studies of sugar chains of glycoprotein and glycolipid are known, there are few examples of studies of the sugar chain function of a glycoside of a natural drug, and the role of a sugar chain of a glycoside for its pharmacologic action expression is unknown. Therefore, as a biological tool investigating the function of a sugar chain of a natural glycoside, we have begun to synthesize a useful "glycoside" which can be utilized as a lead compound having activity.
DOI 10.1248/yakushi.130.679
ISSN 0031-6903
PMID 20460864