イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 日本語
発行・発表の年月 2009/09
形態種別 原著論文
査読 査読有り
標題 Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products.
執筆形態 共著
掲載誌名 Journal of agricultural and food chemistry
掲載区分国外
巻・号・頁 57(17),7666-72頁
著者・共著者 Motomura Keita, Fujiwara Yukio, Kiyota Naoko, Tsurushima Keiichiro, Takeya Motohiro, Nohara Toshihiro, Nagai Ryoji, Ikeda Tsuyoshi
概要 Because advanced glycation end product (AGE) inhibitors such as pyridoxamine significantly inhibit the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with AGE inhibitors is believed to be a potential strategy for the prevention of lifestyle-related diseases such as diabetic complications. A crude extract of Astragali Radix (AR; roots of Astragalus membranaceus ) inhibits the formation of N(epsilon)-(carboxymethyl)lysine (CML) and pentosidine during the incubation of bovine serum albumin with ribose. In the present study, compounds were isolated from AR that prevented CML and pentosidine formation. Astragalosides significantly inhibited the formation of both CML and pentosidine, and astragaloside V had the strongest inhibitory effect among all if the isolated compounds. These data suggest that AR and astragalosides may be a potentially useful strategy for the prevention of clinical diabetic complications by inhibiting AGEs.
DOI 10.1021/jf9007168
ISSN 1520-5118
PMID 19681610