Ikeda Tsuyoshi
   Department   SOJO UNIVERSITY  Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES
     /(DC)Division of Pharmaceutical Sciences,
Language English
Publication Date 2008/04
Peer Review Peer reviewed
Title Some natural compounds enhance N epsilon-(carboxymethyl)lysine formation.
Contribution Type
Journal Annals of the New York Academy of Sciences
Journal TypeAnother Country
Volume, Issue, Page 1126,pp.152-4
Author and coauthor Fujiwara Yukio, Kiyota Naoko, Motomura Keita, Mera Katsumi, Takeya Motohiro, Ikeda Tsuyoshi, Nagai Ryoji
Details However, the paradoxical effect of green tea has been reported; although plasma hydroperoxide levels were ameliorated, the level of N epsilon-(carboxyethyl)lysine (CML) in tendon and plasma was increased by the oral administration of green tea to diabetic rats. In the present study, we measured the effect of natural compounds on CML formation by enzyme-linked immunosorbent assay. A significant amount of CML was observed when bovine serum albumin was incubated with ribose for 7 days. Under the same conditions, natural compounds, such as desgalactotigonin, showed inhibitory effects, whereas quercetin and acteoside enhanced CML formation, indicating that natural compounds contain both inhibitors and enhancers for CML formation.
DOI 10.1196/annals.1433.015
ISSN 0077-8923
PMID 18079486