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Ikeda Tsuyoshi
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES /(DC)Division of Pharmaceutical Sciences, Position |
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| Language | English |
| Publication Date | 2008/04 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Some natural compounds enhance N epsilon-(carboxymethyl)lysine formation. |
| Contribution Type | |
| Journal | Annals of the New York Academy of Sciences |
| Journal Type | Another Country |
| Volume, Issue, Page | 1126,pp.152-4 |
| Author and coauthor | Fujiwara Yukio, Kiyota Naoko, Motomura Keita, Mera Katsumi, Takeya Motohiro, Ikeda Tsuyoshi, Nagai Ryoji |
| Details | However, the paradoxical effect of green tea has been reported; although plasma hydroperoxide levels were ameliorated, the level of N epsilon-(carboxyethyl)lysine (CML) in tendon and plasma was increased by the oral administration of green tea to diabetic rats. In the present study, we measured the effect of natural compounds on CML formation by enzyme-linked immunosorbent assay. A significant amount of CML was observed when bovine serum albumin was incubated with ribose for 7 days. Under the same conditions, natural compounds, such as desgalactotigonin, showed inhibitory effects, whereas quercetin and acteoside enhanced CML formation, indicating that natural compounds contain both inhibitors and enhancers for CML formation. |
| DOI | 10.1196/annals.1433.015 |
| ISSN | 0077-8923 |
| PMID | 18079486 |