イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2008/04
形態種別 原著論文
査読 査読有り
標題 Some natural compounds enhance N epsilon-(carboxymethyl)lysine formation.
執筆形態 共著
掲載誌名 Annals of the New York Academy of Sciences
掲載区分国外
巻・号・頁 1126,pp.152-4
著者・共著者 Fujiwara Yukio, Kiyota Naoko, Motomura Keita, Mera Katsumi, Takeya Motohiro, Ikeda Tsuyoshi, Nagai Ryoji
概要 However, the paradoxical effect of green tea has been reported; although plasma hydroperoxide levels were ameliorated, the level of N epsilon-(carboxyethyl)lysine (CML) in tendon and plasma was increased by the oral administration of green tea to diabetic rats. In the present study, we measured the effect of natural compounds on CML formation by enzyme-linked immunosorbent assay. A significant amount of CML was observed when bovine serum albumin was incubated with ribose for 7 days. Under the same conditions, natural compounds, such as desgalactotigonin, showed inhibitory effects, whereas quercetin and acteoside enhanced CML formation, indicating that natural compounds contain both inhibitors and enhancers for CML formation.
DOI 10.1196/annals.1433.015
ISSN 0077-8923
PMID 18079486