イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2007/11
形態種別 原著論文
査読 査読有り
標題 Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT.
執筆形態 共著
掲載誌名 Arteriosclerosis, thrombosis, and vascular biology
掲載区分国外
巻・号・頁 27(11),pp.2400-6
著者・共著者 Fujiwara Yukio, Kiyota Naoko, Hori Masaharu, Matsushita Sayaka, Iijima Yoko, Aoki Koh, Shibata Daisuke, Takeya Motohiro, Ikeda Tsuyoshi, Nohara Toshihiro, Nagai Ryoji
概要 METHODS AND RESULTS:Esculeogenin A significantly inhibited the accumulation of cholesterol ester (CE) induced by acetylated low density lipoprotein (acetyl-LDL) in human monocyte-derived macrophages (HMDM) in a dose-dependent manner without inhibiting triglyceride accumulation, however, it did not inhibit the association of acetyl-LDL to the cells. Esculeogenin A also inhibited CE formation in Chinese hamster ovary cells overexpressing acyl-coenzymeA (CoA): cholesterol acyl-transferase (ACAT)-1 or ACAT-2, suggesting that esculeogenin A suppresses the activity of both ACAT-1 and ACAT-2. Furthermore, esculeogenin A prevented the expression of ACAT-1 protein, whereas that of SR-A and SR-BI was not suppressed. Oral administration of esculeoside A to apoE-deficient mice significantly reduced the levels of serum cholesterol, triglycerides, LDL-cholesterol, and the areas of atherosclerotic lesions without any detectable side effects.
DOI 10.1161/ATVBAHA.107.147405
ISSN 1524-4636
PMID 17872457