イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2006/09
形態種別 原著論文
標題 Metabolism of tomato steroidal glycosides in humans.
執筆形態 共著
掲載誌名 Chemical & pharmaceutical bulletin
掲載区分国外
巻・号・頁 54(9),pp.1312-4
著者・共著者 Noguchi Eishin, Fujiwara Yukio, Matsushita Sayaka, Ikeda Tsuyoshi, Ono Masateru, Nohara Toshihiro
概要 Recently, commercial natural foods composed of diosgenin have been used for the treatment of diseases such as osteoporosis and premenstrual syndrome in women. It is anticipated that diosgenin would be metabolized into a type of steroidal hormone, for instance progesterone, however, this metabolism has not been confirmed. Therefore, we have examined the metabolites in the urine of subjects who ingested tomatoes, which contain a considerable amount of the steroidal glycoside esculeoside A. The occurrence of steroidal hormones in the metabolites has been recognized. It has been proven that when a steroidal glycoside is administered, it is partly metabolized into a type of steroidal hormone exhibiting various physiological activities.
DOI 10.1248/cpb.54.1312
ISSN 0009-2363
PMID 16946542