イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2005/09
形態種別 原著論文
査読 査読有り
標題 Anti-herpes virus type 1 activity of oleanane-type triterpenoids.
執筆形態 共著
掲載誌名 Biological & pharmaceutical bulletin
掲載区分国外
巻・号・頁 28(9),pp.1779-81
著者・共著者 Ikeda Tsuyoshi, Yokomizo Kazumi, Okawa Masafumi, Tsuchihashi Ryota, Kinjo Junei, Nohara Toshihiro, Uyeda Masaru
概要 Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 activity, its sapogenol, glycyrrhetic acid, showed 10 times greater action than glycyrrhizin. Therefore, the in vivo anti-HSV-1 activity of glycyrrhizin administered orally could be reasonably attributed to glycyrrhetic acid generated by hydrolysis by intestinal bacteria. Since the activity of soyasapogenol A was less than 1/20 of that of soyasapogenol B, the hydroxylation at C-21 seemed to reduce anti-HSV-1 activity. Since kudzusapogenol A, abrisapogenols B and C lacked the activity, the C-29 hydroxy group would eliminate anti-HSV-1 activity. On the other hand, since the methylesters of kudzusapogenol B and glycyrrhetic acid exhibited greater action, a methoxy carboxy group at C-20 might enhance activity.
DOI 10.1248/bpb.28.1779
ISSN 0918-6158
PMID 16141560