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Ikeda Tsuyoshi
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES /(DC)Division of Pharmaceutical Sciences, Position |
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| Language | English |
| Publication Date | 2017/02 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenylated flavonoids |
| Contribution Type | |
| Journal | J. Periodontal Res. |
| Journal Type | Another Country |
| Publisher | Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| Volume, Issue, Page | 52(1),pp.89-96 |
| Author and coauthor | Kariu T., Nakao R., Ikeda T., Imamura T. |
| Details | RESULTS:
We isolated 17 prenylated flavonoids (Limonianin, Epimedokoreanin B, etc.) from Epimedium species. We found that some prenylated flavonoids inhibited gingipain activity in a non-competitive manner with Ki values at μm order. The prenylated flavonoids also hindered growth and biofilm formation of P. gingivalis, in a manner independent of gingipain inhibition by the compounds. CONCLUSION: The results indicated an inhibitory effect of the prenylated flavonoids against P. gingivalis and would provide useful information for future development of periodontitis treatment that suppresses gingipains, P. gingivalis growth and biofilm formation. |