イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2018/01
形態種別 原著論文
標題 Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation.
執筆形態 共著
掲載誌名 Journal of clinical and experimental hematopathology : JCEH
掲載区分国外
巻・号・頁 58(1),pp.17-23
著者・共著者 Fujiwara Yukio, Saito Yoichi, Shiota Takuya, Cheng Pan, Ikeda Tsuyoshi, Ohnishi Koji, Takeya Motohiro, Komohara Yoshihiro
概要 In the present study, we searched for natural compounds that regulate the CD169-positive phenotype in macrophages to identify potential new anti-cancer agents targeting macrophage activation. Among 50 natural compounds, aculeatiside A, naringin, and onionin A significantly induced the CD169-positive phenotype in human monocyte-derived macrophages. These compounds also induced CD169 overexpression and secretion of inflammatory cytokines, including interleukin (IL)-1β and IL-12, in murine macrophages. Subcutaneous injection of aculeatiside A and naringin enhanced mRNA expression of IL-1β, IL12, and CD169 in regional lymph nodes in mice. These findings suggest aculeatiside A and naringin may enhance anti-tumor immune responses by inducing CD169-positive macrophages in lymph nodes.
DOI 10.3960/jslrt.17032
ISSN 1880-9952
PMID 29553092