イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2016/07
形態種別 原著論文
査読 査読有り
標題 Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.
執筆形態 共著
掲載誌名 Scientific reports
掲載区分国外
巻・号・頁 6,pp.29588
著者・共著者 Tsuboki Junko, Fujiwara Yukio, Horlad Hasita, Shiraishi Daisuke, Nohara Toshihiro, Tayama Shingo, Motohara Takeshi, Saito Yoichi, Ikeda Tsuyoshi, Takaishi Kiyomi, Tashiro Hironori, Yonemoto Yukihiro, Katabuchi Hidetaka, Takeya Motohiro, Komohara Yoshihiro
概要 In the present study, we investigated whether ONA had a therapeutic anti-ovarian cancer effect using in vitro and in vivo studies. We found that ONA reduced the extent of ovarian cancer cell proliferation induced by co-culture with human macrophages. In addition, we also found that ONA directly suppressed cancer cell proliferation. A combinatorial effect with ONA and anti-cancer drugs was also observed. The activation of signal transducer and activator of transcription 3 (STAT3), which is involved in cell proliferation and chemo-resistance, was significantly abrogated by ONA in ovarian cancer cells. Furthermore, the administration of ONA suppressed cancer progression and prolonged the survival time in a murine ovarian cancer model under single and combined treatment conditions. Thus, ONA is considered useful for the additional treatment of patients with ovarian cancer owing to its suppression of the protumour activation of TAMs and direct cytotoxicity against cancer cells.
DOI 10.1038/srep29588
ISSN 2045-2322
PMID 27404320