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Ikeda Tsuyoshi
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES /(DC)Division of Pharmaceutical Sciences, Position |
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| Language | English |
| Publication Date | 2013/12 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. |
| Contribution Type | |
| Journal | Oncology letters |
| Journal Type | Another Country |
| Volume, Issue, Page | 6(6),pp.1619-1623 |
| Author and coauthor | Fujiwara Yukio, Takaishi Kiyomi, Nakao Junko, Ikeda Tsuyoshi, Katabuchi Hidetaka, Takeya Motohiro, Komohara Yoshihiro |
| Details | The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. CA also markedly enhanced the anticancer effect of paclitaxel, cisplatin and doxorubicin. In addition, CA abrogated the cell-cell interactions between macrophages and epithelial ovarian cancer cells and inhibited the macrophage-induced activation of epithelial ovarian cancer cells. These data indicated that CA was able to reverse the chemoresistance of epithelial ovarian cancer cells and suppress the cell-cell interaction with tumorigenic macrophages. Thus, CA may be useful as an adjuvant treatment to patients with advanced ovarian and other types of cancer due to the multiple anticancer effects. |
| DOI | 10.3892/ol.2013.1591 |
| ISSN | 1792-1074 |
| PMID | 24260055 |