イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2013/12
形態種別 原著論文
査読 査読有り
標題 Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling.
執筆形態 共著
掲載誌名 Oncology letters
掲載区分国外
巻・号・頁 6(6),pp.1619-1623
著者・共著者 Fujiwara Yukio, Takaishi Kiyomi, Nakao Junko, Ikeda Tsuyoshi, Katabuchi Hidetaka, Takeya Motohiro, Komohara Yoshihiro
概要 The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. CA also markedly enhanced the anticancer effect of paclitaxel, cisplatin and doxorubicin. In addition, CA abrogated the cell-cell interactions between macrophages and epithelial ovarian cancer cells and inhibited the macrophage-induced activation of epithelial ovarian cancer cells. These data indicated that CA was able to reverse the chemoresistance of epithelial ovarian cancer cells and suppress the cell-cell interaction with tumorigenic macrophages. Thus, CA may be useful as an adjuvant treatment to patients with advanced ovarian and other types of cancer due to the multiple anticancer effects.
DOI 10.3892/ol.2013.1591
ISSN 1792-1074
PMID 24260055