イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2013/04
形態種別 原著論文
査読 査読有り
標題 Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) against ATL cell lines and structure-activity relationships with withanolides isolated from solanaceous plants.
執筆形態 共著
掲載誌名 Journal of natural medicines
掲載区分国外
巻・号・頁 67(2),pp.415-20
著者・共著者 Nakano Daisuke, Ishitsuka Kenji, Katsuya Hiroo, Kunami Naoko, Nogami Rumiko, Yoshimura Yuka, Matsuda Michika, Kamikawa Mio, Tsuchihashi Ryota, Okawa Masafumi, Ikeda Tsuyoshi, Nohara Toshihiro, Tamura Kazuo, Kinjo Junei
概要 Adult T-cell leukemia/lymphoma (ATL) is an incurable peripheral T-cell malignancy caused by human T-cell lymphotropic virus type I. In our preceding paper, 214 extracts from 162 plants were screened to elucidate the antiproliferative principles against ATL cell lines. Several withanolides were isolated and the structure-activity relationships (SAR) examined. To extend the search for SAR, 31 further withanolides, previously isolated from solanaceous plants, were tested against ATL cell lines. The presence of a 4β-hydroxy group as well as a 5β,6β-epoxy group appeared to be essential for the activity. In contrast, the presence of a sugar moiety at either the 3- or the 27-position led to a reduction in the activity. Furthermore, 24,25-dihydrowithanolide D (13) was identified as the most potent inhibitor, showing selective toxicity against ATL cell lines by inducing apoptotic cell death.
DOI 10.1007/s11418-012-0700-9
ISSN 1861-0293
PMID 22961603