イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2013/07
形態種別 原著論文
査読 査読有り
標題 Cyclic sulfoxides garlicnins B2, B3, B4, C2, and C3 from Allium sativum.
執筆形態 共著
掲載誌名 Chemical & pharmaceutical bulletin
掲載区分国外
巻・号・頁 61(7),pp.695-9
著者・共著者 Nohara Toshihiro, Fujiwara Yukio, Ikeda Tsuyoshi, Murakami Kohtaro, Ono Masateru, Nakano Daisuke, Kinjo Junei
概要 Several novel sulfides, called garlicnins B2 (1), B3 (2), B4 (3), C2 (4), and C3 (5), were isolated from acetone extracts of garlic, Allium sativum L. and characterized. These garlicnins are capable of suppressing M2 macrophage activation and they have a novel skeleton of cyclic sulfoxide. The structures of the former 3 and latter of 2 were deduced to be 2-(sulfenic acid)-5-(allyl)-3,4-dimethyltetrahydrothiophene-S-oxides and 2-(allyldithiine)-5-(propenylsulfoxide)-3,4-dimethyltetrahydrothiophene-S-oxides, respectively. The mechanism of the proposed production of these compounds is discussed. The identification of these novel sulfoxides from garlic accumulates a great deal of new chemistry in the Allium sulfide field, and future pharmacological investigations of these compounds will aid the development of natural, healthy foods and anti-cancer agents that may prevent or combat disease.
DOI 10.1248/cpb.c13-00082
ISSN 1347-5223
PMID 23812395