イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2012
形態種別 原著論文
査読 査読有り
標題 Garlicnins B(1), C(1), and D, from the fraction regulating macrophage activation of Allium sativum.
執筆形態 共著
掲載誌名 Chemical & pharmaceutical bulletin
掲載区分国外
巻・号・頁 60(6),pp.747-51
著者・共著者 Nohara Toshihiro, Kiyota Yuka, Sakamoto Toyonobu, Manabe Hideyuki, Ono Masateru, Ikeda Tsuyoshi, Fujiwara Yukio, Nakano Daisuke, Kinjo Junei
概要 Several novel sulfides from acetone extracts of bulbs of garlic (Allium sativum L.), were identified and investigated. These were named garlicnins B(1) (1), C(1) (2), and D (3), and they were found to have the ability to control macrophage activation. Garlicnins B(1) (1) and C(1) (2) possess a new skeleton of cyclic sulfoxide and their structures of garlicnins B(1) (1) and C(1) (2) were characterized as 3,4-dimethyltetrahydrothiophene-S-oxide derivatives carrying the substitutions of a propenyl and a sulfenic acid, and an allyldithiine and a 1-propene-sulfenic acid (a), respectively. The identification of these novel sufoxides from onion and garlic accumulates a great deal of new chemistry to the Allium sulfide field, and future pharmacological investigations aid the development of natural, healthy foods and anti-cancer agents that could potentially prevent or combat disease.
DOI 10.1248/cpb.60.747
ISSN 1347-5223
PMID 22689426