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Ikeda Tsuyoshi
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES /(DC)Division of Pharmaceutical Sciences, Position |
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| Language | English |
| Publication Date | 2011/05 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages. |
| Contribution Type | |
| Journal | Journal of agricultural and food chemistry |
| Journal Type | Another Country |
| Volume, Issue, Page | 59(9),pp.4544-52 |
| Author and coauthor | Fujiwara Yukio, Hayashida Akinori, Tsurushima Keiichiro, Nagai Ryoji, Yoshitomi Makiko, Daiguji Norika, Sakashita Naomi, Takeya Motohiro, Tsukamoto Sachiko, Ikeda Tsuyoshi |
| Details | Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis. |
| DOI | 10.1021/jf200193r |
| ISSN | 1520-5118 |
| PMID | 21446758 |