Ikeda Tsuyoshi
   Department   SOJO UNIVERSITY  Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES
     /(DC)Division of Pharmaceutical Sciences,
Language English
Publication Date 2011/05
Peer Review Peer reviewed
Title Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages.
Contribution Type
Journal Journal of agricultural and food chemistry
Journal TypeAnother Country
Volume, Issue, Page 59(9),pp.4544-52
Author and coauthor Fujiwara Yukio, Hayashida Akinori, Tsurushima Keiichiro, Nagai Ryoji, Yoshitomi Makiko, Daiguji Norika, Sakashita Naomi, Takeya Motohiro, Tsukamoto Sachiko, Ikeda Tsuyoshi
Details Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis.
DOI 10.1021/jf200193r
ISSN 1520-5118
PMID 21446758