イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2011/04
形態種別 原著論文
査読 査読有り
標題 Natural compounds containing a catechol group enhance the formation of Nε-(carboxymethyl)lysine of the Maillard reaction.
執筆形態 共著
掲載誌名 Free radical biology & medicine
掲載区分国外
巻・号・頁 50(7),pp.883-91
著者・共著者 Fujiwara Yukio, Kiyota Naoko, Tsurushima Keiichiro, Yoshitomi Makiko, Mera Katsumi, Sakashita Naomi, Takeya Motohiro, Ikeda Tsuyoshi, Araki Tomohiro, Nohara Toshihiro, Nagai Ryoji
概要 Even though 1mM 4-methylcatechol, epicatechin, and gallic acid significantly enhanced CML formation from gHSA, it was significantly inhibited by decreasing their concentration. The enhancing effect of 1mM catechol compounds was inhibited in the presence of the glutathione peroxidase system, thus demonstrating that hydrogen peroxide generated from catechol compounds plays an important role in the enhancement of CML formation. Furthermore, administration of 500mg/kg/day epicatechin to STZ-induced diabetic mice for 45days enhanced CML accumulation at the surface area of gastric epithelial cells in the stomach. This study provides the first evidence that high amounts of catechol-containing structures enhance oxidative stress, thus leading to enhanced CML formation, and this phenomenon may explain the paradoxical effect that some flavonoids have on redox status.
DOI 10.1016/j.freeradbiomed.2010.12.033
ISSN 1873-4596
PMID 21195168