イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2010/08
形態種別 原著論文
査読 査読有り
標題 HSP70 inducers from Chinese herbs and their effect on melanin production.
執筆形態 共著
掲載誌名 Experimental dermatology
掲載区分国外
巻・号・頁 19(8),pp.e340-2
著者・共著者 Yamashita Yasuhiro, Hoshino Tatsuya, Matsuda Minoru, Kobayashi Chisa, Tominaga Aya, Nakamura Yasuhiko, Nakashima Koumei, Yokomizo Kazumi, Ikeda Tsuyoshi, Mineda Kazutaka, Maji Daisuke, Niwano Yoshimi, Mizushima Tohru
概要 In this study, we searched for HSP70 inducers from Chinese herbs and selected an ethanol extract of Eupatorium lindleyanum (E. lindleyanum). Not only melanin production but also the activity and expression of tyrosinase were significantly suppressed in cells treated with E. lindleyanum extract as well as in HSP70-overexpressing cells. The expression of MITF was clearly suppressed in cells treated with E. lindleyanum extract but not in HSP70-overexpressing cells. These results suggest that E. lindleyanum extract suppresses the expression of tyrosinase and melanin production through both HSP70-dependent and HSP70-independent mechanisms.
DOI 10.1111/j.1600-0625.2009.01061.x
ISSN 1600-0625
PMID 20163455