ヤマサキ ケイシ   Yamasaki Keishi
  山﨑 啓之
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2014
形態種別 原著論文
査読 査読有り
標題 An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta.
執筆形態 共著
掲載誌名 Natural product research
掲載区分国外
巻・号・頁 28(23),pp.2211-3
著者・共著者 Taguchi Kazuaki, Yamasaki Keishi, Maesaki Hiroki, Tokuno Masahiro, Okazaki Shoko, Moriuchi Hiroshi, Takeshita Keizo, Otagiri Masaki, Seo Hakaru
概要 Hemerocallis fulva L. var. sempervirens M. Hotta (kwanso) represents an exceptional resource for identifying and developing new phytomedicines for the treatment and prevention of disease. The aim of this study was to conduct a detailed investigation of the biological activities of kwanso. Our study resulted in four major findings. First, kwanso scavenges hydroxyl radicals generated by H(2)O(2)/UV light system in vitro in a dose-dependent manner. Second, hepatic glutathione levels were significantly increased when kwanso was orally administered to mice. Third, the oral administration of kwanso to mice showed a tendency to suppress hepatic injury induced by acetaminophen. Finally, kwanso slightly inhibited cytochrome P450 3A activity. These results provide useful evidence in support of the development of kwanso as a candidate raw material for the treatment and prevention of disease.
DOI 10.1080/14786419.2014.919285
ISSN 1478-6427
PMID 24854051