イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2018/03
形態種別 原著論文
査読 査読有り
標題 Inhibitory Effects of Trehalose Liposomes against Breast Cancer Cells Leading to Apoptosis in vitro
執筆形態 共著
掲載誌名 Journal of Nanomedicine and Biotherapeutic Discovery
掲載区分国外
出版社・発行元 OMICS
巻・号・頁 8,pp.1000157-1-1000157-5
著者・共著者 K. Kuwabara, H. Ichihara, Y. Matsumoto
概要 In this study, the effect of trehalose liposomes (DMTreC14) constituted using α-D- glycopyranosyl-α-Dglucopyranoside monomyristate (TreC14) and L-α- dimyristoylphosphatidylcholine, on the growth of the human breast cancer cell-line, MCF-7 was examined. It was observed that DMTreC14 had an inhibitory effect on the growth of MCF-7 cells and caused apoptosis. This was attributed to DMTreC14 induced decrease in mitochondrial membrane potential followed by the release of cytochrome-c and activation of caspase-6 and caspase-9 in MCF-7 cells. Furthermore, it was observed that there was an increased accumulation of DMTreC14 in the cell membrane of MCF-7 cells, followed by an increase in the fluidity of the cell membrane. In addition, activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) was also observed upon treatment with DMTreC14.
DOI 10.4172/2155-983X.1000157