イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2017/01
形態種別 原著論文
査読 査読有り
標題 Inhibitory effects and anti-invasive activities of trehalose liposomes on the proliferation of lung carcinoma cells
執筆形態 共著
掲載誌名 Journal of Carcinogenesis & Mutagenesis
掲載区分国外
出版社・発行元 OMICS
巻・号・頁 8(1),pp.1000283-1-1000283-5
著者・共著者 K. Kuwabara, H. Ichihara, Y. Matsumoto
概要 Inhibitory effects and anti-invasive activities of trehalose liposomes (DMTreC14)on the proliferation of human non-small cell lung carcinoma (A549) cells were examined in vitro. DMTreC14 with a hydrodynamic diameter less than 100 nm, were preserved for 4 weeks. The inhibitory effects of DMTreC14 on the proliferation of A549 cells accompanied with apoptosis was obtained. Enhancement of the accumulation of DMTreC14 into A549 membranes was observed. An increase in cellular membrane fluidity of A549 cell treated with DMTreC14 was observed on the basis of fluorescence depolarization method. DMTreC14 caused apoptosis for A549 cells through the activation of caspases and mitochondrial pathway. The anti-migration effects of DMTreC14 for A549 cells were observed through the inhibition of filopodia formation. The anti-invasion effects with the reduction of MMP-14 of DMTreC14 for A549 cells were obtained.
DOI 10.4172/2157-2518.1000283