イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2015
形態種別 総説
査読 査読有り
招待論文 招待あり
標題 Chemotherapy and detection of cancer using hybrid liposomes
執筆形態 共著
掲載誌名 International Journal of Complex Systems - Comuputing, Sensing and Control
掲載区分国外
出版社・発行元 TSI Press
巻・号・頁 3(2),pp.155-168
著者・共著者 H. Ichihara, Y. Matsumoto, R. Ueoka
概要 The uniform and stable structure of HL composed ofDMPC and C12(EO)n with a diameter of 80 nm was revealed. The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. Induction of apoptosis by HL was obtained and the pathway of apoptosis induced by HL was clarified. A good correlation between the membrane fluidity of HL and inhibitory effects of HL for tumor cells was obtained. Significantly prolonged survival and remarkable reduction of tumor volume were obtained using mice model of carcinoma after the treatment with HL without any side effects in vivo. In clinical applications, prolonged survival and remarkable reduction of neoplasm were attained in patients with lymphoma treated with HL without any side effects after the approval of the bioethics committee. Furthermore, Specific accumulation and growth inhibitory effects of HL were obtained in human tumor cells without affecting normal cells at all in vivo.