イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2015/05
形態種別 原著論文
査読 査読有り
標題 Therapeutic effects of hybrid liposomes with downregulation of inflammatory cytokine for model mice of rheumatoid arthritis in vivo
執筆形態 共著
掲載誌名 Bioorganic & Medicinal Chemistry Letters
掲載区分国外
巻・号・頁 25(13),pp.2686-2689
著者・共著者 H. Ichihara, S. Yamasaki, M. Hino, R. Ueoka, Y. Matsumoto
概要 Therapeutic effects of HL for a collagen-induced arthritis (CIA) mouse models of HL-23 composed of
95 mol % L-a-dimyristoylphosphatidylcholine (DMPC) and 5 mol % polyoxyethylenedodecylether (C12(EO)23) in vivo were examined. Remarkably high therapeutic effects of HL-23 for CIA mouse models
were obtained on the basis of clinical assessment of arthritis. The reduction of hyperplastic synovial
membrane (pannus tissue) and destruction of the cartilage and bone by HL-23 was revealed on the basis
of hematoxylin and eosin (HE) and safranin O staining. Furthermore, the downregulation of inflammatory
cytokines such as interleukin (IL)-1b, tumor necrosis factor (TNF)-a, and IL-6 for CIA mouse models treated
with HL-23 were investigated. Remarkably high therapeutic effects without joint swelling were
obtained in CIA mouse models treated with HL-23.
DOI doi: 10.1016/j.bmcl.2015.04.083.