イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2013/06
形態種別 原著論文
査読 査読有り
標題 Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells
執筆形態 共著
掲載誌名 Cancer Medicine
掲載区分国外
巻・号・頁 2(3),pp.267-276
著者・共著者 Kitajima H, Komizu Y, Ichihara H, Goto K, Ueoka R
概要 Antitumor effects of hybrid liposomes (HL) composed of DMPC and C12(EO)23 on the metastatic growth of murine osteosarcoma (LM8) cells were investigated in vitro and in vivo. Remarkable inhibitory effects of HL-23 on the growth of LM8 cells were obtained through the induction of apoptotic cell death in vitro. HL-23 should dramatically suppress the invasion of LM8 cells and the formation of filopodia on the cell surface in vitro. Furthermore, significantly high therapeutic effects were observed in the homograft mouse models of LM8 cells with lung metastasis after the treatment with HL-23 in vivo. That is, the histological analysis demonstrated that the primary tumor growth of LM8 cells implanted subcutaneously into the mice was inhibited along with the induction of apoptosis. In addition, it was found that HL-23 significantly decreased the lung metastasis of LM8 cells in the mouse models through the inhibition of primary tumor invasion.
DOI 10.1002/cam4.67