イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2012/08
形態種別 原著論文
査読 査読有り
標題 New cancer immunotherapy using autologous lymphocytes activated with Trastuzumab
執筆形態 共著
掲載誌名 Biological and Pharmaceutical Bulletin
掲載区分国内
巻・号・頁 35(8),pp.1213-1215
著者・共著者 Nakagawa S, Matsuoka Y, Ichihara H, Yoshida H, Yoshida K, Ueoka R
概要 It is well known that trastuzumab (TTZ) is molecular target drug for breast cancer overexpressing human epidermal growth factor receptor 2 (HER2). Novel immunotherapy by human peripheral blood mononuclear cells (PBMCs) activated with TTZ were examined. Proliferation of lymphocytes after adding of TTZ was obtained. Furthermore, lymphocytes activated with TTZ inhibited growth of breast cancer cells in vitro. It is noteworthy that remarkably high cellular cytotoxicity in lymphocytes activated with TTZ compared with that of CD3- and lymphokine (interleukin (IL)2)-activated killer (CD3-LAK) cells commonly used in immunotherapy were revealed.
DOI 10.1248/bpb.b12-00378