イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2011/06
形態種別 単行本
招待論文 招待あり
標題 Membrane Targeted Chemotherapy with Hybr id Liposomes for Tumor Cells Leading to Apoptosis
執筆形態 共著
掲載誌名 The special issue of Current Pharmaceutical Designs
掲載区分国外
出版社・発行元 Bentham Science Publishers
巻・号・頁 17(17),pp.1709-1719
著者・共著者 Ueoka R, Matsumoto Y, Goto K, Ichihara H, Komizu Y
概要 We have employed HL for chemotherapy and interesting results are as follows; (A) The uniform and stable structure of HL composed of L-alfa-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylenedodecyl ether (C12(EO)n) with a diameter of 80 nm was revealed. (B) The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. (C) Induction of apoptosis by HL was obtained and the pathway of apoptosis induced by HL was clarified. (D) A good correlation between the membrane fluidity of HL and inhibitory effects of HL for tumor cells was obtained. (E) Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL without any side effects in vivo. (F) In clinical applications, prolonged survival and remarkable reduction of neoplasm were attained in patients with lymphoma after the treatment with HL without any side effects after the approval of the bioethics committee.
DOI 10.2174/138161211796355128