イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2002/08
形態種別 単行本
標題 Chemotherapy with Hybrid Liposomes Composed of Dimyristoylphosphatidylcholine and Polyoxyethylenealkyl Ether without Drugs
執筆形態 共著
掲載誌名 ACS SYMPOSIUM SERIES 830, Biological systems Engineering, Am. Chem. Soc. Books
掲載区分国外
出版社・発行元 American Chemical Society
巻・号・頁 830,pp.177-189
著者・共著者 Ueoka R, Matsumoto Y, Ichihara H, Kiyokawa T
概要 Highly inhibitory effects of hybrid liposomes were obtained on the growth of tumor cells in vitro. Induction of apoptosis by hybrid liposomes through activation of caspase-3 was verified using flow cytometry and microphysiometer. Significantly prolonged survival was obtained in mice inoculated tumor cells after the treatment with hybrid liposomes without any side effect. In clinical applications, prolonged survival was attained in patients with lymphoma after the intravenous injection of hybrid liposomes without drugs and the remarkable reduction of solid tumor was obtained after the local administration of hybrid liposomes.
DOI 10.1021/bk-2002-0830.fw001
ISBN 9780841237964