イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2011/03
形態種別 原著論文
査読 査読有り
標題 Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis in vivo
執筆形態 共著
掲載誌名 International Journal of Pharmaceutics
掲載区分国外
巻・号・頁 406(1-2),pp.173-178
著者・共著者 Ichihara H, Ueno J, Umebayashi M, Matsumoto Y, Ueoka R
概要 Hybrid liposomes (HL) composed of 95 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 5 mol% polyoxyethylene (25) dodecyl ether (C12(EO)25) were prepared by sonication. A clear solutions of HL-25 having hydrodynamic diameter of about 50 nm could be maintained over 3 weeks. Remarkable reduction of tumor volume in model mice of acute lymphatic leukemia (ALL) intravenously treated with HL-25 without drugs after the subcutaneously inoculation of human ALL (MOLT-4) cells was verified in vivo. Induction of apoptosis in tumor of model mice of ALL treated with HL-25 was observed in micrographs on the basis of TUNEL method. Remarkable decrease of the ascites in ALL model mice treated with HL-25 was observed.
DOI 10.1016/j.ijpharm.2010.12.041