イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2011/01
形態種別 原著論文
査読 査読有り
標題 Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis
執筆形態 共著
掲載誌名 Bioorganic & Medicinal Chemistry Letters
掲載区分国外
巻・号・頁 21(1),pp.207-210
著者・共著者 Ichihara H, Hino M, Makizono T, Umebayashi M, Matsumoto Y, Ueoka R
概要 Inhibitory effects of HL-n composed of 95 mol% L-α-dimyristoylphosphatidylcholin (DMPC) and 5 mol% polyoxyethylenedodecylether (C12(EO)n, n = 21, 23, or 25) on the growth of human rheumatoid arthritis (RA) fibroblast-like synoviocytes (HFLS-RA) in vitro were examined. Remarkably high inhibitory effects of HL-n on the growth of HFLS-RA cells were obtained. The induction of apoptosis by HL-n was revealed on the basis of TUNEL method. Furthermore, the therapeutic effects of HL-23 using mouse models of arthritis were investigated. Therapeutic effects without joint swelling were obtained in mouse models of RA treated with HL.
DOI 10.1016/j.bmcl.2010.11.035