スギウラ マサハル   Sugiura Masaharu
  杉浦 正晴
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2014/10
形態種別 原著論文
標題 O-Monoacyltartaric Acid-Catalyzed Enantioselective Conjugate Addition of a Boronic Acid to Dienones: Application to the Synthesis of Optically Active Cyclopentenones.
執筆形態 共著
掲載誌名 Org. Lett.
掲載区分国外
巻・号・頁 16,pp.5172-5175
著者・共著者 Sugiura, M.; Kinoshita, R.; Nakajima, M.
概要 © 2014 American Chemical Society.Enantioselective conjugate addition of styrylboronic acid to dienones was effectively catalyzed by an O-monoacyltartaric acid to afford monostyrylated products with good enantioselectivity. The RCM of the monostyrylated products using the Hoveyda-Grubbs II catalyst afforded optically active cyclopentenones, including a synthetic intermediate of the antitumor agent TEI-9826. The study shows that a diene additive such as 1,6-heptadiene or diallyl ether was essential for the RCM.
DOI 10.1021/ol502526y
ISSN 15237060
PMID 25248134
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