スギウラ マサハル   Sugiura Masaharu
  杉浦 正晴
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2006/08
形態種別 総説
査読 査読有り
標題 Immobilization of osmium catalysts for asymmetric dihydroxylation of olefins
執筆形態 共著
掲載誌名 Advanced Synthesis and Catalysis
掲載区分国外
巻・号・頁 348,pp.1496-1504
著者・共著者 Shu Kobayashi, Masaharu Sugiura
概要 Osmium-catalyzed asymmetric dihydroxylation provides powerful synthetic routes to optically active vicinal diols from olefins with high enantioselectivity. High catalytic efficiency using only 0.2-1.0 mol% of the osmium catalyst has been attained, and the chiral ligand may be recoverable in large-scale synthesis by extraction with dilute sulfuric acid. However, in spite of the significant advances in this transformation, high toxicity and volatility of the osmium components as well as possible contamination of toxic osmium species in the products have been obstacles for industrial applications. To address this issue, considerable efforts have been devoted to immobilization of the osmium catalyst. This review summarizes several promising methods for immobilization of the osmium components, especially focusing on solid phase-supported osmium catalysts for asymmetric dihydroxylation. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
DOI 10.1002/adsc.200606210
ISSN 16154150
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