コミズ ユウジ   Komizu Yuuji
  古水 雄志
   所属   崇城大学  生物生命学部 生物生命学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   准教授
言語種別 日本語
発行・発表の年月 2011/06
形態種別 総説
査読 査読あり
招待論文 招待あり
標題 Membrane targeted chemotherapy with hybrid liposomes for tumor cells leading to apoptosis
執筆形態 共著
掲載誌名 Curr. Pharm. Des.
巻・号・頁 17(17),1709-1719頁
著者・共著者 Ueoka R, Matsumoto Y, Goto K, Ichihara H, Komizu Y
概要 We have employed hybrid liposomes (HL) for chemotherapy and interesting results are as follows; (A) The uniform and stable structure of HL composed of DMPC and polyoxyethylenedodecyl ether with a diameter of 80 nm was revealed. (B) The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. (C) Induction of apoptosis by HL was obtained and the pathway of apoptosis induced by HL was clarified. (D) A good correlation between the membrane fluidity of HL and inhibitory effects of HL for tumor cells was obtained. (E) Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL without any side effects in vivo. (F) In clinical applications, prolonged survival and remarkable reduction of neoplasm were attained in patients with lymphoma after the treatment with HL without any side effects after the approval of the bioethics committee.
DOI 10.2174/138161211796355128