コミズ　ユウジ   Komizu Yuuji   古水　雄志    所属   崇城大学  生物生命学部 生物生命学科    崇城大学大学院  工学研究科 応用生命科学専攻（博士前期課程）    崇城大学  生物生命学部 応用生命科学科    崇城大学大学院  工学研究科 応用生命科学専攻（博士後期課程）    職種   准教授
言語種別	英語
発行・発表の年月	2012/11
形態種別	原著論文
査読	査読あり
標題	Therapeutic effects of hybrid liposomes for mouse models of adult T-cell leukemia/ lymphoma in vivo
執筆形態	共著
掲載誌名	Nano Bull.
巻・号・頁	1(1),pp.120105-1-4
著者・共著者	Komizu Y, Yukihara M, Ueoka T, Ichihara H, Matsumoto Y, Okada, S, Ueoka R
概要	Hybrid liposomes (HLs) composed 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(25) dodecyl ether (C12(EO)25), having a hydrodynamic diameter of 20-80 nm, were preserved for a period of one month. Remarkably high therapeutic effects were obtained in the mouse models of adult T-cell leukemia/lymphoma (ATLL) after the treatment with HLs on the basis of relative organ weight; histological analysis of the liver tissue sections of the mouse models of ATLL was done with hematoxylin-eosin (HE) and immunohistochemical staining. Furthermore, prolonged survival was obtained in the mouse models of ATLL after the treatment with HLs. It is noteworthy that the therapeutic effect of HLs without any drugs in the mouse models of ATLL was revealed on the basis of histological analysis and life prolongation rates for the first time in vivo.