コミズ ユウジ   Komizu Yuuji
  古水 雄志
   所属   崇城大学  生物生命学部 生物生命学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   准教授
言語種別 英語
発行・発表の年月 2012/02
形態種別 原著論文
査読 査読あり
標題 Selective accumulation and growth inhibition of hybrid liposomes to human hepatocellular carcinoma cells in relation to fluidity of plasma membranes
執筆形態 共著
掲載誌名 Biochem. Biophys. Res. Commun.
巻・号・頁 418(1),pp.81-86
著者・共著者 Komizu Y, Ueoka H, Ueoka R
概要 Hybrid liposomes (HLs), composed of l-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(23) dodecyl ether, have selectively inhibited the growth of human hepatocellular carcinoma (HCC) cells without affecting normal hepatocytes to trigger apoptosis via caspase-3 activation. Furthermore, HLs distinguished between the HCC and normal cells which had higher and lower membrane fluidities respectively, then fused and accumulated preferentially into the membranes of HCC cells. It is noteworthy that the anti-cancer activity of HLs correlated well with the fluidity of cell membranes for HCC and other cancer cells. These results suggest that HLs could target cancer cell-membranes in relation to their lipid fluidity that provide the possibility of novel nanotherapy for intractable cancer.
DOI http://dx.doi.org/10.1016/j.bbrc.2011.12.134