コミズ ユウジ   Komizu Yuuji
  古水 雄志
   所属   崇城大学  生物生命学部 生物生命学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   准教授
言語種別 英語
発行・発表の年月 2011/03
形態種別 原著論文
査読 査読あり
標題 Specific interaction between Ca2+and anionic lipids in cancer cells along with apoptosis
執筆形態 共著
掲載誌名 Biol. Pharm. Bull.
巻・号・頁 34(3),pp.439-442
著者・共著者 Goto K, Tatsumi K, Nagata T, Komizu Y, Ueoka R
概要 Markedly inhibitory effects of Ca2+ on the growth of human tumor cells were attained through the induction of apoptosis in vitro. On the other hand, a good correlation between the growth inhibition effects of Ca2+ and the amounts of phosphatidylserines (PS) in the cell membranes (plasma membranes) was obtained. Furthermore, the decrease of membrane fluidity and the localization of lipid microdomains in the cell membranes were observed in the presence of Ca2+. The findings in this study suggest that Ca2+ could induce apoptosis toward tumor cells through the localization of lipid rafts in plasma membranes by the specific interactions between extracellular Ca2+ and PS.
DOI http://dx.doi.org/10.1248/bpb.34.439