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    (Last updated : 2022-10-24 17:54:24)
  Ookuri Takatoshi
   Department   SOJO UNIVERSITY  Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES
   Position  
■ Book and thesis
1. 2022/06 Article Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity. The Journal of Biochemistry 172(1),pp.49-56 (Collaboration) 
2. 2021/10 Article High-level expression of human CH2 domain from the Fc region in Pichia pastoris and preparation of anti-CH2 antibodies. The Journal of Biochemistry 170(2),pp.289-297 (Collaboration) 
3. 2021/06 Article A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab. Scientific reports 11(1),pp.12937 (Collaboration) 
4. 2021/06 Article Abolition of aggregation of CH 2 domain of human IgG1 when combining glycosylation and protein stabilization Biochem Biophys Res Commun. 18(558),pp.114-119 (Collaboration) 
5. 2021/04 Article Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris. The Journal of Biochemistry 29(169),pp.435-443 (Collaboration) 
Display all(44)
■ Academic conference presentation
1. 2019/09/20 Introduction of a glycosylation site in the constant region of human Fab and effect of the effect of glycosylation on the properties of the Fab
2. 2019/06/25 Preparation of C-terminal specific PEG modified Fab with intermolecular disulfide bond
■ Academic background
1. 1990/04~1994/03 Faculty of Pharmaceutical Science, Fukuoka University, Graduated,
2. 1994/04~1996/03 〔Master Course〕, Graduate School, Division of Pharmaceutical Sciences, Kyushu University, Completed,
3. 1996/04~1999/03 〔Doctorial Course〕, Graduate School, Division of Pharmaceutical Sciences, Kyushu University, Completed,
■ Business career
1. 2002/04~2008/03 Research Assistant
2. 2008/04~2009/09 Assistant Professor
3. 2009/10~2020/03 SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
4. 2012/04~ /(DC)Division of Pharmaceutical Sciences
■ Home Page
   http://www.ph.sojo-u.ac.jp/~ohkuri/index.html
■ E-Mail Address
  kyoin_mail
■ Present specialized field
Pharmaceutical analytical chemistry and physicochemistry, Immunology, Pharmaceutical analytical chemistry and physicochemistry 
■ Department laboratory expense researcher number
70346807
■ 
1.  :  Link