教員情報 - 方　軍

1.	1998	論文	Expression of standard and variant CD44 in human lung cancer Zhonghua Jie He He Hu Xi Za Zhi 21(９),541-543頁（共著）
2.	1999	論文	Circumferential resection and "Z"-shape plastic end-to-end anastomosis of canine trachea Chin Med J (Engl) 112(3),pp.278-280 （共著）
3.	2002	論文	Pegylated zinc portoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity Bioconjug Chem 13(5),pp.1031-1038 （共著）
4.	2002	論文	Tumor-targeted Delivery of Polyethylene Glycol-conjugated D-Amino Acid Oxidase for Antitumor Therapy via Enzymatic Generation of Hydrogen Peroxide Cancer Res 62(11),pp.3138-3143 （共著）
5.	2003	論文	Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour Br J Cancer 88,pp.902-909 （共著）
6.	2003	論文	Factors and mechanism of EPR effect and the enhanced antitumor effects of macromolecular drugs including SAMNCS Adv Exp Med Biol 519,pp.29-49 （共著）
7.	2003	論文	In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor Cancer Res 63(13),pp.3567-3574 （共著）
8.	2003	論文	Macromolecular anticancer therapeutics for effective solid tumor targeting: advantages and prospects Clin. Pharmacokinet 42(13),pp.1089-1115 （共著）
9.	2003	論文	Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin I2 analogue beraprost sodium J Drug Target 11(1),pp.45-52 （共著）
10.	2003	論文	Vascular permeability enhancement in solid tumor: various factors, mechanisms and implication Int Immunopharm 3(3),pp.319-328 （共著）
11.	2004	論文	Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment Apoptosis 9(1),pp.27-35 （共著）
12.	2004	論文	Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin Int J Cancer 109(1),pp.1-8 （共著）
13.	2004	論文	SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours J Control Release 97(2),pp.219-230 （共著）
14.	2005	論文	An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface J Biol Chem 280,pp.1740-1745 （共著）
15.	2005	論文	Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity Bioconjug Chem 16(1),pp.230-236 （共著）
16.	2005	著書	Factors and mechanism of EPR effect and clinical outlook of SMANCS Cancer Chemoprevention and Drug Therapy of the New Millenium pp.197-212 （共著）
17.	2005/10	論文	癌・炎症と物質動態：高分子薬剤のEPR効果と癌治療を中心に 21(12),49-58頁（共著）
18.	2006	著書	Enhanced permeability and retention (EPR) effect and tumor-selective delivery of anticancer drugs Delivery of Protein and Peptide Drugs in Cancer pp.37-52 （共著）
19.	2006	論文	EPR effect and polymeric drugs: challenge for a paradigm shift for cancer chemotherapy in the 21st century Adv Polym Sci 193,pp.103-121 （共著）
20.	2006	論文	Exploiting the enhanced permeability and retention effect for tumor targeting Drug Discov Today 11(17-18),pp.812-818 （共著）
21.	2006	論文	The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma Mol Pharmacol 70(6),pp.2108-2115 （共著）
22.	2007	論文	High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor Biomaterials 28(10),pp.1871-1881 （共著）
23.	2007	論文	Tumor-targeted induction of oxystress for cancer therapy J Drug Target 15(7),pp.475-486 （共著）
24.	2008	論文	Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy J Exp Clin Cancer Res 27,pp.13 （共著）
25.	2008	論文	Oxystress inducing antitumor therapeutics via targeted delivery of PEG-conjugated D-amino acid oxidase Int J Cancer 122(5),pp.1135-1144 （共著）
26.	2009	論文	Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application Cancer Sci 100(12),pp.2426-2430 （共著）
27.	2009	論文	Generation of drug-resistant mutants of Helicobacer pylori in the presence of peroxynitrite, a derivative of nitric oxide, at pathophysiological concentration Microbiol Immunol 53(1),pp.1-7 （共著）
28.	2009	論文	Pretreatment with glutamine attenuates anoxia/reoxygenation injury of human proximal renal tubular epithelial cells via induction of heme oxygenase-1 Pharmacology 84(1),pp.1-8 （共著）
29.	2009	論文	SMA-copolymer conjugate of AHPP: a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect J Control Release 135(3),pp.211-217 （共著）
30.	2009	論文	Therapeutic strategies by modulating oxygen stress in cancer and inflammation Adv Drug Deliv Rev 61(4),pp.290-302 （共著）
31.	2009	著書	Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effects in solid tumor Pharmacrutical Perspective of Cancers Therapeutics pp.93-102 （共著）
32.	2010	論文	Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrene-maleic acid copolymer) and (4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemia-reperfusion injury Exp Biol Med (Maywood) 235(4),pp.487-496 （共著）
33.	2011	論文	4-Amino-6-hydroxypyrazolo [3,4-d]pyrimidine (AHPP) conjugated PEG micelles: Water soluble polymeric xanthine oxidase inhibitor J Drug Target 19(10),pp.954-966 （共著）
34.	2011	論文	Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; Unique intracellular disintegration of SMA micelles J Control Release 155(3),pp.367-375 （共著）
35.	2011	論文	The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Adv Drug Deliv Rev 63,pp.136-151 （共著）
36.	2011	論文	Therapeutic potential of pegylated hemin for ROS-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model J Pharmacol Exp Ther 339(3),pp.779-789 （共著）
37.	2012	論文	Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention (EPR) effect of solid tumor Cancer Sci 103(3),pp.535-541 （共著）
38.	2012	論文	HSP32 (HO-1) inhibitor, copoly(styrene maleic acid)-zinc protoporphyrin IX, a water soluble micelle as anticancer agent: in vitro and in vivo anticancer effect Eur J Pharm. Biopharm 81(3),pp.540-547 （共著）
39.	2012	論文	PEGylated D-amino acid oxidase restores bactericidal activity of neutrophils in chronic granulomatous disease via hypochlorite Exp Biol Med (Maywood) 237(6),pp.703-708 （共著）
40.	2012	著書	PEGylated zinc protoporphyrin: a micelle forming polymeric drug for cancer therapy Nanotechnology in Health Care pp.169-191 （共著）
41.	2012	論文	Protective Role of D-Amino Acid Oxidase Against Staphylococcus aureus infection Infect Immun 80(4),pp.1546-1553 （共著）
42.	2012	論文	S-Nitrosated Human Serum Albumin Dimer is not only a Novel Anti-Tumor Drug but also a Potentiator for Anti-Tumor Drugs with Augmented EPR Effects Bioconjug Chem 23(2),pp.264-271 （共著）
43.	2012	論文	Styrene-co-maleic Acid (SMA) Telomeric Micelles Encapsulated-Zinc Protoporphyrin (SMA-ZnPP) and Other Drugs: Stability Study CRS Newsletter 29,pp.6-7 （共著）
44.	2013	論文	Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo J Control Release 165(3),pp.191-198 （共著）
45.	2013	論文	Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involve suppression of oxidative stress and inflammatory cytokines Carcinogenesis 34(12),pp.2833-2841 （共著）
46.	2013	論文	The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo Adv Drug Deliv Rev 65(1),pp.71-79 （共著）
47.	2013	論文	Tissue-Protective Effect of Glutamine on Hepatic Ischemia-Reperfusion Injury via Induction of Heme Oxygenase-1 Pharmacology 91(1-2),pp.59-68 （共著）
48.	2014	論文	Bufalin loaded biotinylated chitosan nanoparticles: An efficient drug delivery system for targeted chemotherapy against breast carcinoma. Eur J Pharm Biopharm. 87(3),pp.445-453 （共著）
49.	2014	論文	Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease. J Control Release 187,pp.14-21 （共著）
50.	2014	論文	Enhanced Bacterial Tumor Delivery by Modulating the EPR Effect and Therapeutic Potential of Lactobacillus casei J Pharm Sci. 103(10),pp.3235-3243 （共著）
51.	2014	論文	Tuning of poly-s-nitrosated human serum albumin as superior antitumor nanomedicine. J Pharm Sci. 1037(7),pp.2184-2188 （共著）
52.	2014	論文	Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage J Control Release 174C,pp.81-87 （共著）
53.	2014	論文	Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity. BMC Cancer 14(1),pp.436 （共著）
54.	2015	論文	Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice Eur J Pharm Biopharm. 90,pp.90-96 （共著）
55.	2015	論文	Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor Eur J Pharm Biopharm. 89,pp.259-270 （共著）
56.	2015	論文	Enhanced permeability and retention effect based nanomedicine, a solution for cancer World J Pharmcology 4(2),pp.168-171 （単著）
57.	2015	論文	HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases Target Oncol. （共著）
58.	2015	論文	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin Future Sci. OA pp.FSO4 （共著）
59.	2015	論文	Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy via the generation of nitric oxide. Cancer Sci. 106(2),pp.194-200 （共著）
60.	2015	論文	S-Nitrosated human serum albumin dimer as novel nano EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes J Control Release 217,pp.1-9 （共著）
61.	2015	論文	Sp1-driven up-regulation of miR-19a decreases RHOB and promotes pancreatic cancer Oncotarget. 6(19),pp.17391-17403 （共著）
62.	2015	論文	Styrene-maleic acid-copolymer conjugated zinc protoporphyrin as a candidate drug for tumor-targeted therapy and imaging J Drug Target. （共著）
63.	2015	論文	Synthesis and therapeutic effect of styrene-maleic acid copolymer conjugated pirarubicin. Cancer Sci. 106(3),pp.270-278 （共著）
64.	2015/11	論文	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin. Future Sci. OA. （共著）
65.	2015/12	論文	pH sensitive polymeric complex of cisplatin with hyaluronic acid exhibits tumor-targeted delivery and improved in vivo antitumor effect. Int J Pharm. （共著）
66.	2016	論文	Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect. Methods Mol Biol. （共著）
67.	2016/02	論文	HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases. （共著）
68.	2016/02	論文	pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect. Colloids Surf B Biointerfaces （共著）
69.	2016/02	論文	Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases. （共著）
70.	2016/04	論文	A Retrospective 30 Years After Discovery of the EPR Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic-therapy-Problems, Solutions, Prospects Microcirculation （共著）
71.	2016/05	論文	Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect （共著）
72.	2016/06	論文	Styrene-maleic acid-copolymer conjugated zinc protoporphyrin as a candidate drug for tumor-targeted therapy and imaging. （共著）
73.	2016/12	論文	Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin. Mol Pharm. （共著）
74.	2017/08	論文	Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate. Eur J Pharm Sci. （共著）
75.	2017/09	論文	Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer. Biomaterials. （共著）
76.	2017/12	論文	Styrene maleic acid encapsulated raloxifene micelles for management of inflammatory bowel disease. Clin Transl Med. （共著）
77.	2018/01	論文	HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study. Int J Pharm. （共著）
78.	2018/09	論文	N-(2-hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging. Eur J Pharm Biopharm. （共著）
79.	2018/12	論文	Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines. Mol Cancer Ther. （共著）
80.	2019/06	論文	Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors Photochem Photobiol Sci. 18(6),pp.1304-1314 （共著）
81.	2019/07	論文	Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents. Pharmaceutics. 11(7),pp.E343 （共著）
82.	2019/07	論文	Synthesis of Pegylated Manganese Protoporphyrin as a Catalase Mimic and Its Therapeutic Application to Acetaminophen-Induced Acute Liver Failure. 42(7),pp.1199-1206 （共著）
83.	2019/12	論文	Styrene-maleic acid copolymer-encapsulated carbon monoxide releasing molecule-2 (SMA/CORM-2) suppresses proliferation, migration and invasion of colorectal cancer cells in vitro and in vivo. Biochem Biophys Res Commun. 520(2),pp.320-326 （共著）
84.	2020/04	論文	Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization. Acta Biomater. 106,pp.256-266 （共著）
85.	2020/07	論文	Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity. Nutrients. 12(8),pp.2279 （共著）
86.	2020/07	論文	Moderating Role of Health Literacy on the Association between Alexithymia and Depressive Symptoms in Middle School Students. 17(15),pp.5321 （共著）
87.	2020/12	論文	Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers. Adv Drug Deliv Rev. 157,pp.142-160 （共著）
88.	2020/12	論文	Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study. Pharmaceutics. 12(12),pp.1242 （共著）
89.	2021/01	論文	Factors affecting the dynamics and heterogeneity of the EPR effect: pathophysiological and pathoanatomic features, drug formulations and physicochemical factors. Expert Opin Drug Deliv. pp.1-24 （共著）
90.	2021/01	論文	Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration. J Control Release. 331,pp.350-363 （共著）
91.	2021/02	論文	Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis. Biomaterials. 269,pp.120631 （共著）
92.	2021/03	論文	Tumor Environment-Responsive Hyaluronan Conjugated Zinc Protoporphyrin for Targeted Anticancer Photodynamic Therapy. J. Pers. Med. 11,pp.136 （共著）
93.	2021/04	論文	Metabolic reprogramming of macrophages and its involvement in inflammatory diseases. 20,pp.628-641 （共著）
94.	2021/05	論文	EPR-Effect Enhancers Strongly Potentiate Tumor-Targeted Delivery of Nanomedicines to Advanced Cancers: Further Extension to Enhancement of the Therapeutic Effect. J Pers Med. 11(6),pp.487 （共著）
95.	2021/05	論文	Unraveling the role of Intralipid in suppressing off-target delivery and augmenting the therapeutic effects of anticancer nanomedicines. Acta Biomater. 126,pp.372-383 （共著）
96.	2021/07	論文	Development of a Selective Tumor-Targeted Drug Delivery System: Hydroxypropyl-Acrylamide Polymer-Conjugated Pirarubicin (P-THP) for Pediatric Solid Tumors. Cancers (Basel). 13(15),pp.3698 （共著）
97.	2021/08	論文	Interaction of smoking and being bullied on suicidal behaviors: a school-based cross-sectional survey in China. Environ Health Prev Med. 26(1),pp.79 （共著）
98.	2021/10	論文	Styrene Maleic Acid Copolymer-Based Micellar Formation of Temoporfin (SMA@ mTHPC) Behaves as A Nanoprobe for Tumor-Targeted Photodynamic Therapy with A Superior Safety. Biomedicines. 9(10),pp.1493 （共著）
99.	2021/11	論文	Inadequate Mental Health Literacy and Insufficient Physical Activity Potentially Increase the Risks of Anxiety and Depressive Symptoms in Chinese College Students. Front Psychiatry. 12,pp.753695 （共著）
100.	2021/12	論文	Chronic cadmium exposure induces epithelial mesenchymal transition in prostate cancer cells through a TGF-β-independent, endoplasmic reticulum stress induced pathway. Toxicol Lett. 353,pp.107 （共著）
101.	2021/12	論文	Expression Dynamics of Heme Oxygenase-1 in Tumor Cells and the Host Contributes to the Progression of Tumors. J Pers Med. 11(12),pp.1340 （共著）
102.	2021/12	論文	The Journey of an Outstanding Scientific Mind: Prof Hiroshi Maeda (1938-2021). J Pers Med. 11(12),pp.1362 （共著）
103.	2022/01	論文	EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer. J Pers Med. 12(1),pp.95 （単著）
104.	2022/01	論文	Nano-designed CO donor ameliorates bleomycin-induced pulmonary fibrosis via macrophage manipulation. J Control Release. 341,pp.566 （共著）
105.	2022/01	論文	Patterns of six behaviors and psychosomatic symptoms in adolescents: A six-province study in China. J Affect Disord. 297,pp.593 （共著）
106.	2022/02	論文	Factors affecting the dynamics and heterogeneity of the EPR effect: pathophysiological and pathoanatomic features, drug formulations and physicochemical factors. Expert Opin Drug Deliv. 19(2),pp.199 （共著）
107.	2022/02	論文	Mediating Effect of Sleep Disorder Between Low Mental Health Literacy and Depressive Symptoms Among Medical Students: The Roles of Gender and Grade. Front Psychiatry. 13,pp.818295 （共著）
108.	2022/03	論文	Poly(styrene-co-maleic acid) Micelle of Photosensitizers for Targeted Photodynamic Therapy, Exhibits Prolonged Singlet Oxygen Generating Capacity and Superior Intracellular Uptake. J Pers Med. 12(3),pp.493 （共著）
109.	2022/03	論文	Treatment with Polyethylene Glycol-Conjugated Fungal D-Amino Acid Oxidase Reduces Lung Inflammation in a Mouse Model of Chronic Granulomatous Disease. Inflammation 45(4),pp.1668 （共著）
110.	2022/04	論文	Decrease of Hyaluronidase Activity and Suppression of Mouse CD4+ T Lymphocyte Activation by Tomato Juice Saponin Esculeoside B, and Its Sapogenol Esculeogenin B. J Pers Med. 12(4),pp.579 （共著）
111.	2022/04	論文	Tumor Stimulus-Responsive Biodegradable Diblock Copolymer Conjugates as Efficient Anti-Cancer Nanomedicines. J Pers Med. 12(5),pp.698 （共著）
112.	2022/05	論文	Nanoformulation of a carbon monoxide releasing molecule protects against cyclosporin A-induced nephrotoxicity and renal fibrosis via the suppression of the NLRP3 inflammasome mediated TGF-β/Smad pathway. Acta Biomater. 144,pp.42 （共著）
113.	2022/05	論文	Singlet Oxygen In Vivo: It Is All about Intensity J Pers Med. 12(6),pp.891 （共著）
114.	2022/07	論文	Association Between the Patterns of Five Unhealthy Behaviors and Suicidal Behaviors Among Adolescents in Six Provinces of China. Front Psychiatry. 13,901537頁（共著）
115.	2022/10	論文	Poly(Styrene-Co-Maleic Acid)-Conjugated 6-Aminofluorescein and Rhodamine Micelle as Macromolecular Fluorescent Probes for Micro-Tumors Detection and Imaging. J Pers Med. 12(10),pp.1650 （共著）
116.	2022/11	論文	Polymer nanomedicines with enzymatically triggered activation: A comparative study of in vitro and in vivo anti-cancer efficacy related to the spacer structure. Nanomedicine. 46,pp.102597 （共著）
117.	2023/01	論文	HPMA copolymer conjugated 5-aminolevulinic acid exhibits superior efficacy for photodynamic therapy with tumor-responsive and targeting properties. Nanomedicine. 48,pp.102636 （共著）
5件表示
全件表示(117件)

■ 学会発表

1.	2001/07/13	Preparation of poly(ethylene glycol) conjugated D-amino acid oxidase and its antitumor activity based on tumor-targeted delivery and generation of hydrogen peroxide（Intl. Symposium on Polymer Therapeutics）
2.	2002/09/23	Pegylated zinc protoporphyrin for cancer therapy: an antitumor strategy by targeted inhibition of heme oxygenase-1 in solid tumor（2nd Intl. Symposium & Exposition on Tumor Targeted Delivery System (CRS/NCI)）
3.	2003/07/20	Oxidation Chemotherapy via Targeted Delivery of Pegylated D-Amino Acid Oxidase and Pegylated Zinc Protoprophyrin Based on EPR Effect（30th Annual Meeting and Exposition of Controlled Release Society）
4.	2004/03/27	The H+-linked monocarboxylate transporter (MCT1/SLC16A1): A potential target in neuroblastoma（95th Annual Meeting of the American Association for Cancer Research）
5.	2004/11/08	The H+-linked monocarboxylate transporter (MCT1/SLC16A1): A potential target in neuroblastoma（International Conference on Tumor progression and Therapeutic Resistance）
6.	2006/07/22	Copoly(styrene-maleic acid)-Zinc protoporphyrin: a potent antitumor agent via targeted inhibition of heme oxygenase in solid tumor（33rd Annual Meeting & Exposition of the Controlled Release Society）
7.	2007/03/15	Oxidation dependent anticancer therapy via targeted induction of oxystress in solid tumor（The 1st Sojo Frontier Seminar in Pharmaceutical Sciences）
8.	2007/07/11	Oxystress induced antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase（34th Annual Meeting & Exposition of the Controlled Release Society）
9.	2008/06/12	Oxystress induced antitumor therapy using hydrogen peroxide generated by tumor-targeted delivery of PEG-conjugated D-amino acid oxidase（BIT World Cancer Congress 2008）
10.	2008/10/03	Oxystress-induced antitumor therapeutics via targeted-inhibiting heme oxygenase 1 (HSP32) in tumor（Ehrlich II 2nd World Conference on Magic Bullets）
11.	2009/07/18	SMA-copolymer conjugates of AHPP: a polymeric inhibitor of xanthine oxidase with therapeutic potentials against hypertension（The 36th Annual Meeting and Exposition of the Controlled Release Society）
12.	2010/07/10	Pegylated hemin, a water-soluble micelle with therapeutic potential against ischemia-reperfurion injury via induction of heme oxygenase-1（The 37th Annual Meeting and Exposition of the Controlled Release Society）
13.	2011/07/30	Augmentation of EPR effect by heme oxygenase-1 (HO-1)（The 38th Annual Meeting and Exposition of the Controlled Release Society）
14.	2012/05/20	Protection of inflammatory bowel diseases and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) via suppressing oxidative stress（Keystone Symposia 2012 in Dublin）
15.	2012/07/15	Water soluble polymeric xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases（The 39th Annual Meeting and Exposition of the Controlled Release Society）
16.	2013/03/19	Water-soluble polymeric xanthine oxidase inhibitors as a novel therapeutic for ROS related inflammatory diseases（ICBS2013 in Tsukuba）
17.	2013/07/21	Preparation of a water soluble carbon monoxide donor, SMA-CORM2 micelles, and therapeutic potential for inflammatory bowel diseases（The 40th Annual Meeting and Exposition of the Controlled Release Society）
18.	2014/05/19	Micelles of CO releasing molecules encapsulated by styrene-maleic acid copolymer, exhibit therapeutic potential for inflammatory bowel disease with disease-targeting property by EPR effect.（10th International Symposium on Polymer Therapeutics: From laboratory to Clinical Practice）
19.	2014/07/30	細菌による抗癌治療：EPR効果による細菌の腫瘍へのデリバリーとその増強法（第３０回日本DDS学会）
20.	2014/09/25	Upregulation of HO-1 in colorectal cancer with increased circulation CO levels, potentially affects chemosensitivity（73th Annual Meeting of the Japanese Cancer Association）
21.	2015/07/02	腫瘍標的型亜鉛プロトポルフィリンP-HPMAミセルを用いる癌光化学治療とイメジング（第３１回日本DDS学会）
22.	2015/07/26	Styrene-maleic acid copolymer conjugated pirarubicin, an anticancer nanomedicine with good stability and tumor-targeting property（The 42th Annual Meeting and Exposition of the Controlled Release Society）
23.	2015/11/02	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation（International conference on Clinical Sciences and Drug Discovery (CDDD-2015)）
24.	2015/11/23	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation.（Symposium of 30 Years Anniversary of the EPR Effect: Revolution in Tumor Drug Delivery using Nanomedicine.）
25.	2015/11/30	Upregulation of HO-1 in colorectal cancer with increased circulation CO levels, potentially affects chemosensitivity.（The 20th Japan-Korea Cancer Research Workshop）
26.	2016/05/20	Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases.（The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide）
27.	2016/05/23	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation（11th International Symposium on Polymers Therapeutics From Laboratory to Clinical Practice.）
28.	2016/06/30	In vivo evaluation and comparison of P-HPMA-pirarubicin conjugates with different molecular weights（32nd Annual Meeting of the Japan Society of Drug Delivery System）
29.	2016/09/07	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation.（International Conference on Pharmaceutical Chemistry）
30.	2016/10/06	In vivo evaluation and comparison of P-HPMA-pirarubicin conjugates with different molecular weights（75th Annual Meeting of the Japanese Cancer Association）
31.	2017/07/06	Investigation the effect of NO donor on enhancing EPR effect（33rd Annual Meeting of the Japan Society of Drug Delivery System.）
32.	2017/07/16	Augmentation of tumor-targeted photodynamic therapy and imaging by modulating tumor microenvironment using nitric oxide generating agents（The 44th Annual Meeting and Exposition of the Controlled Release Society）
33.	2018/06/21	Development of HPMA polymer conjugated phropheophorbide-a as a cancer theranostic probe（34th Annual Meeting of the Japan Society of Drug Delivery System.）
34.	2018/08/20	N-(2-Hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging（International Conference on Medicinal Chemistry & Drug Design）
35.	2018/09/27	Polymeric pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging.（77th Annual Meeting of the Japanese Cancer Association）
36.	2019/06/27	Improving therapeutic effect of nanomedicine by EPR enhancers.（83th Prague Meeting on Macromolecules.）
37.	2019/07/05	Augmentation of EPR effect by using carbon monoxide generators.（35th Annual Meeting of the Japan Society of Drug Delivery System.）
38.	2019/07/23	Polymeric pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging.（The 46th Annual Meeting and Exposition of the Controlled Release Society）
39.	2019/09/27	Augmentation of EPR effect and therapeutic efficacy of nanomedicine by carbon monoxide generating agents.（78th Annual Meeting of the Japanese Cancer Association）
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■ 学歴

1999/04～2003/03

熊本大学大学院医学研究科病態制御学専攻微生物学分野博士課程修了博士

■ 職歴

1.	2003/09～2005/03	Duke University Medical Center Department of Pathology 博士研究員
2.	2005/04～2010/03	崇城大学薬学部薬学科講師
3.	2010/04～	崇城大学薬学部薬学科准教授
4.	2012/04～	崇城大学大学院薬学研究科薬学専攻指導教員

■ 教育上の能力

●教育方法の実践例
1.	2012/04～	講義に対する学生の理解度のチェック、評価
●作成した教科書、教材
1.	2007/04～	崇城大学薬学部「生物系薬学実習（微生物学実習）」実習書
●その他教育活動上特記すべき事項
1.	2007/04～	授業参観
2.	2007/08	実務実習指導薬剤師養成ワークショップ

■ 主要学科目

DDS学、腫瘍学、化学療法学、微生物学、細胞生物学

■ 所属学会

1.		Controlled release Soeiely (CRS)
2.		日本DDS学会
3.		∟ 評議員
4.		日本癌学会
5.		日本薬学会

■ researchmap研究者コード

B000346537

■ 社会における活動

2008～

卒業研究

■ 研究課題・受託研究・科研費

1.	2019/04～2022/03	EPR効果におけるオフターゲットデリバリーの抑制によるナノメディシンの効果増強基盤研究(C) （キーワード：EPR効果、オフターゲットデリバリー、ナノメディシン、Intralipid、効果増強）
2.	2016/04～2019/03	腫瘍微小循環改善に着目したEPR効果増強法とそれによる併用化学療法の探索基盤研究C
3.	2013/04～2016/03	診断と治療が同時に可能な腫瘍標的型亜鉛プロトポルフィリンミセルの設計と有用性評価基盤研究(C)
4.	2013/04～2014/03	微小癌の検出・治療を目的としたセラノスティック薬剤の開発その他の補助金・助成金
5.	2011/04～2014/03	蛍光内視鏡をめざした高分子型分子プローブの創製その他の補助金・助成金
6.	2010/04～2013/03	亜鉛プロトポルフィリン含有高分子ミセルとキセノン光源を用いる癌の光化学療法の研究若手研究(B)
7.	2008/04～2010/03	HSP32を標的とする高分子型制癌剤PEG化亜鉛プロトポルフィリン(ZnP) 特定領域研究
8.	2008/04～2011/03	抗ラジカル型抗炎症剤XO阻害剤AHPPの新しいSMA-ミセル化剤の研究基盤研究(C)
9.	2006/04～2007/03	新しいミセル素材SMAの開発とそのZnプロトポルフィリン包含ミセルSMA-ZnPPの抗癌活性その他の補助金・助成金
10.	2005/04～2008/03	EPR効果に基づく活性酸素生成型高分子薬の固形癌ターゲティング療法特定領域研究
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全件表示(10件)

■ メールアドレス

■ 現在の専門分野

DDS, 腫瘍治療学, 微生物学, 実験病理学, 腫瘍生物学　（キーワード：DDS、ナノメディシン、腫瘍標的、EPR効果、活性酸素、一酸化炭素）

■ 取得特許

1.		抗炎症剤（特開2010-013411）
2.		高分子型蛍光分子プローブ（特願2011-193237）

■ 科研費研究者番号

20412736

■ 担当経験のある科目

1.	微生物学III（化学療法論）（崇城大学薬学部）

■ 高校生のための研究紹介

1.	高分子薬剤を用いる炎症・癌に対する治療法の開発

■ 産官学連携シーズ情報

1.	分野：ライフサイエンスより効果の高いがん治療法を探究する〜腫瘍微小循環改善に着目したEPR効果増強法とそれによる併用化学療法の探索〜 EPR効果、がん、ナノメディシン、腫瘍ターゲティング、高分子薬剤、ドラッグデリバリーシステム