Faculty Information - Tsukigawa Kenji

Tsukigawa Kenji

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2026	Papers	Mechanistic Insights into pH-Responsive Drug Release and Antitumor Effects of an Albumin-Pirarubicin Conjugate. Pharmaceutical research (Co-authored)
2.	2026/05	Papers	Antitumor efficacy and reduced systemic toxicity of palmitic acid-modified pirarubicin nanoparticles in mice Cancer Chemotherapy and Pharmacology (Co-authored)
3.	2026/03	Papers	Caspase-Independent Cell Death Induced by a Nitric Oxide Donor Derived from Valproic Acid in Human Pancreatic Cancer Cells Biological and Pharmaceutical Bulletin (Co-authored)
4.	2026/01	Papers	Preparation and evaluation of hydrophobin-pirarubicin glucosamine-containing nanoparticles as an anticancer formulation International Journal of Biological Macromolecules,pp.150460-150460 (Co-authored)
5.	2025/12	Papers	Secreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia. Journal of controlled release 391,pp.114567-114567 (Co-authored)
6.	2025/08	Papers	Insights into the renal protective effects of 7-phenylheptanoic acid in chronic kidney disease mice: modulation of indoxyl sulfate production and gut microbiome homeostasis Drug Metabolism and Disposition,pp.100149-100149 (Co-authored)
7.	2024/11	Papers	Ibuprofen‑derived nitric oxide donors with a high affinity to human serum albumin induce cell death in pancreatic cancer cells through a non‑caspase 3/7‑mediated pathway. Biomedical reports 21 (5),pp.159-159 (Co-authored)
8.	2024/09	Papers	Novel Diclofenac-NO Donor With High Affinity for Human Serum Albumin Induces Endoplasmic Reticulum Stress-mediated Cell Death in Human Pancreatic Cancer Cells. Anticancer research 44 (9),pp.3793-3798 (Co-authored)
9.	2024/07	Papers	7-Phenylheptanoic Acid-Hydroxypropyl β-Cyclodextrin Complex Slows the Progression of Renal Failure in Adenine-Induced Chronic Kidney Disease Mice Toxins (Co-authored)
10.	2024/02	Papers	Possible Involvement of Protein Binding Inhibition in Changes in Dexmedetomidine Concentration in Extracorporeal Circuits during Midazolam Use. Biological & pharmaceutical bulletin 47 (2),pp.389-393 (Co-authored)
11.	2024/01	Papers	Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin. Chemical & pharmaceutical bulletin 72 (1),pp.21-27 (Co-authored)
12.	2024/01	Papers	Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate. Pharmaceutics 16 (1) (Co-authored)
13.	2023/10	Papers	Study of the Structural Chemistry of the Inclusion Complexation of 4-Phenylbutyrate and Related Compounds with Cyclodextrins in Solution: Differences in Inclusion Mode with Cavity Size Dependency. International journal of molecular sciences 24 (20) (Co-authored)
14.	2023/09	Papers	Extracellular and intracellular productions of lysophosphatidic acids and cyclic phosphatidic acids by lysophospholipase D from exogenously added lysophosphatidylcholines to cultured NRK52E cells. Biochimica et biophysica acta. Molecular and cell biology of lipids 1868 (9),pp.159349 (Co-authored)
15.	2023/02	Papers	Study of the inclusion complexes formed between 4-phenylbutyrate and α-, β- and γ-cyclodextrin in solution and evaluation on their taste-masking properties. The Journal of pharmacy and pharmacology 75 (2),pp.236-244 (Co-authored)
16.	2023/01	Papers	Structural Basis of the Change in the Interaction Between Mycophenolic Acid and Subdomain IIA of Human Serum Albumin During Renal Failure. Journal of medicinal chemistry 66 (1),pp.951-961 (Co-authored)
17.	2022/06	Papers	Effect of Fatty Acids and Uremic Toxins on the Binding of Nateglinide, an Insulin Secretagogue, to Site II on Human Serum Albumin. Biological & pharmaceutical bulletin 45 (6),pp.803-805 (Co-authored)
18.	2022/03	Papers	The Nitrated Form of Nateglinide Induces Apoptosis in Human Pancreatic Cancer Cells Through a Caspase-dependent Mechanism. Anticancer research 42 (3),pp.1333-1338 (Co-authored)
19.	2022/03	Papers	In Vitro and In Vivo Assessment of Atemoya Fruit (Annona atemoya) for Food-Drug Interactions. European journal of drug metabolism and pharmacokinetics 47 (2),pp.177-185 (Co-authored)
20.	2022/01	Papers	An in-vitro comparative study of the binding of caspofungin and micafungin to plasma proteins. The Journal of pharmacy and pharmacology 74 (1),pp.88-93 (Co-authored)
21.	2021/02	Papers	Possible Role of Electrolytes on the Formation of Precipitates during the Infusion of Nafamostat Mesilate in Hemodialysis. Biological & pharmaceutical bulletin 44 (2),pp.259-265 (Co-authored)
22.	2021/03	Papers	Interaction of Benzbromarone with Subdomains IIIA and IB/IIA on Human Serum Albumin as the Primary and Secondary Binding Regions. Molecular pharmaceutics 18 (3),pp.1061-1070 (Co-authored)
23.	2021/01	Papers	Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin. Pharmaceuticals (Basel, Switzerland) 14 (1) (Co-authored)
24.	2017/08	Papers	Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate European journal of pharmaceutical sciences 106,pp.10-19 (Co-authored)
25.	2016/12	Papers	Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin. Molecular pharmaceutics 13 (12),pp.4106-4115 (Co-authored)
26.	2016/06	Papers	Styrene-maleic acid-copolymer conjugated zinc protoporphyrin as a candidate drug for tumor-targeted therapy and imaging. Journal of drug targeting 24 (5),pp.399-407 (Co-authored)
27.	2016/04	Papers	A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic Therapy--Problems, Solutions, and Prospects. Microcirculation (New York, N.Y. : 1994) 23 (3),pp.173-182 (Co-authored)
28.	2016/02	Papers	pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect. Colloids and surfaces. B, Biointerfaces 138,pp.128-137 (Co-authored)
29.	2015/03	Papers	Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin. Cancer science 106 (3),pp.270-278 (Co-authored)
30.	2015/01	Papers	Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor. European journal of pharmaceutics and biopharmaceutics 89,pp.259-270 (Co-authored)
31.	2013/06	Papers	Characterization of carotenoid fatty acid esters from the peels of the persimmon Diospyros kaki. Chemical & pharmaceutical bulletin 61 (6),pp.666-669 (Co-authored)
32.	2013/02	Papers	Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo. Journal of controlled release : official journal of the Controlled Release Society 165 (3),pp.191-198 (Co-authored)
33.	2012/03	Papers	Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention effect in solid tumors. Cancer science 103 (3),pp.535-541 (Co-authored)
34.	2011/12	Papers	Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model. The Journal of pharmacology and experimental therapeutics 339 (3),pp.779-789 (Co-authored)
35.	2011/11	Papers	Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles. Journal of controlled release : official journal of the Controlled Release Society 155 (3),pp.367-375 (Co-authored)