教員情報 - 中村　仁美

ナカムラ　ヒトミ Nakamura Hitomi
中村　仁美

所属薬学部薬学科

職種講師

著書・論文歴
1.	2026	論文	Chimeric Fab incorporating the IgM Cμ1 domain: Insights into physicochemical properties. J. Biochem. 269,108663 (共著)
2.	2026	論文	Juvenile-specific expression of a phospholipase A₂ isozyme gene in the venom gland of Protobothrops flavoviridis. Toxicon 269,108663 (共著)
3.	2025	論文	Characterization of adalimumab Fab variants with the CH1 domain replaced by the Cα1 domain of IgA. Biochem. Biophys. Rep. 44,102269 (共著)
4.	2025	論文	タンパク質工学的手法による抗体フラグメントFabの高機能化に関する基盤研究 YAKUGAKU ZASSHI 145 (5),395-401頁 (単著)
5.	2024	論文	Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains. Biochem. Biophys. Res. Commun. 700,149592 (共著)
6.	2023	論文	Enhancing thermal stability in the CH₂ domain to suppress aggregation through the introduction of simultaneous disulfide bonds in Pichia pastoris. Protein Sci. 32 (12),e4831 (共著)
7.	2023	論文	Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab. J. Biochem. 174 (4),345-353頁 (共著)
8.	2022	論文	Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity. J. Biochem. 172 (1),49-56頁 (共著)
9.	2021	論文	A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab. Sci. Rep. 11 (1),12937 (共著)
10.	2021	論文	Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris. J. Biochem. 169 (4),435-443頁 (共著)
11.	2020	論文	C-terminal cysteine PEGylation of adalimumab Fab with an engineered interchain SS bond. Biol. Pharm. Bull. 43 (3),418-423頁 (共著)
12.	2019	論文	Alternative mRNA Splicing in Three Venom Families Underlying a Possible Production of Divergent Venom Proteins of the Habu Snake, Protobothrops flavoviridis. Toxins (Basel) (共著)
13.	2018	論文	The habu genome reveals accelerated evolution of venom protein genes. Sci Rep. 8 (1) (共著)
14.	2018	論文	Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab. Biochem. Biophys. Res. Commun. 503 (2),752-756頁 (共著)
15.	2018	論文	A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab. Biochem. Biophys. Res. Commun. 495 (1),7-11頁 (共著)
16.	2016	論文	Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2. Biochim Biophys Acta. 1860 (10),2279-2284頁 (共著)
17.	2014	論文	Epithelium specific ETS transcription factor, ESE-3, of Protobothrops flavoviridis snake venom gland transactivates the promoters of venom phospholipase A₂ isozyme genes. Toxicon 92,133-139頁 (共著)
18.	2014	論文	Discovery of a novel vascular endothelial growth factor (VEGF) with no affinity to heparin in Gloydius tsushimaensis venom. Toxicon 86,107-115頁 (共著)
19.	2011	論文	A [Lys⁴⁹] phospholipase A₂ from Protobothrops flavoviridis venom induces caspase-independent apoptotic cell death accompanied by rapid plasma-membrane rupture in human leukemia cells. Biosci. Biotechnol. Biochem. 75,864-870頁 (共著)