Faculty Information - Nakamura Hitomi

Nakamura Hitomi

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2026	Papers	Chimeric Fab incorporating the IgM Cμ1 domain: Insights into physicochemical properties. J. Biochem. 269,pp.108663 (Co-authored)
2.	2026	Papers	Juvenile-specific expression of a phospholipase A₂ isozyme gene in the venom gland of Protobothrops flavoviridis. Toxicon 269,pp.108663 (Co-authored)
3.	2025	Papers	Characterization of adalimumab Fab variants with the CH1 domain replaced by the Cα1 domain of IgA. Biochem. Biophys. Rep. 44,pp.102269 (Co-authored)
4.	2024	Papers	Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains. Biochem. Biophys. Res. Commun. 700,pp.149592 (Co-authored)
5.	2023	Papers	Enhancing thermal stability in the CH₂ domain to suppress aggregation through the introduction of simultaneous disulfide bonds in Pichia pastoris. Protein Sci. 32 (12),pp.e4831 (Co-authored)
6.	2023	Papers	Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab. J. Biochem. 174 (4),pp.345-353 (Co-authored)
7.	2022	Papers	Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity. J. Biochem. 172 (1),pp.49-56 (Co-authored)
8.	2021	Papers	A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab. Sci. Rep. 11 (1),pp.12937 (Co-authored)
9.	2021	Papers	Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris. J. Biochem. 169 (4),pp.435-443 (Co-authored)
10.	2020	Papers	C-terminal cysteine PEGylation of adalimumab Fab with an engineered interchain SS bond. Biol. Pharm. Bull. 43 (3),pp.418-423 (Co-authored)
11.	2019	Papers	Alternative mRNA Splicing in Three Venom Families Underlying a Possible Production of Divergent Venom Proteins of the Habu Snake, Protobothrops flavoviridis. Toxins (Basel) (Co-authored)
12.	2018	Papers	The habu genome reveals accelerated evolution of venom protein genes. Sci Rep. 8 (1) (Co-authored)
13.	2018	Papers	Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab. Biochem. Biophys. Res. Commun. 503 (2),pp.752-756 (Co-authored)
14.	2018	Papers	A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab. Biochem. Biophys. Res. Commun. 495 (1),pp.7-11 (Co-authored)
15.	2016	Papers	Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2. Biochim Biophys Acta. 1860 (10),pp.2279-2284 (Co-authored)
16.	2014	Papers	Epithelium specific ETS transcription factor, ESE-3, of Protobothrops flavoviridis snake venom gland transactivates the promoters of venom phospholipase A₂ isozyme genes. Toxicon 92,pp.133-139 (Co-authored)
17.	2014	Papers	Discovery of a novel vascular endothelial growth factor (VEGF) with no affinity to heparin in Gloydius tsushimaensis venom. Toxicon 86,pp.107-115 (Co-authored)
18.	2011	Papers	A [Lys⁴⁹] phospholipase A₂ from Protobothrops flavoviridis venom induces caspase-independent apoptotic cell death accompanied by rapid plasma-membrane rupture in human leukemia cells. Biosci. Biotechnol. Biochem. 75,pp.864-870 (Co-authored)