教員情報 - 中村　秀明

ナカムラ　ヒデアキ Nakamura Hideaki
中村　秀明

所属薬学部薬学科

職種准教授

著書・論文歴
1.	2023/02	論文	The G protein-coupled receptor ligand apelin-13 ameliorates skeletal muscle atrophy induced by chronic kidney disease. Journal of cachexia, sarcopenia and muscle 14 (1),553-564 (共著)
2.	2022/12	論文	Recent topics and advanced therapies in chronic granulomatous disease. Human cell (共著)
3.	2022/08	論文	Treatment with Polyethylene Glycol-Conjugated Fungal D-Amino Acid Oxidase Reduces Lung Inflammation in a Mouse Model of Chronic Granulomatous Disease. Inflammation 45 (4),1668-1679 (共著)
4.	2021/05	論文	De novo filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks. FEBS Open Bio 11 (5),1299-1312頁 (共著)
5.	2021/09	論文	Acid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine J Control Release 337,546-556頁 (共著)
6.	2021/01	論文	Preparation of enzymatically highly active pegylated-D-amino acid oxidase and its application to antitumor therapy. Curr Drug Deliv (共著)
7.	2020	論文	Development of Tumor-targeting Antitumor Agents Based on Polymer Effect] Yakugaku Zasshi 140 (10),1243-1249頁 (単著)
8.	2020/05	論文	Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain ACS Applied Bio Materials 3 (5),3005-3014頁 (共著)
9.	2020/04	論文	Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization. Acta Biomater 106,256-266頁 (共著)
10.	2019/07	論文	Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid. Molecular Pharmaceutics (共著)
11.	2019/05	論文	In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease. Nanomaterials 9 (5) (共著)
12.	2018/05	論文	The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype. 18 (1),519 (共著)
13.	2018	論文	Preparation and in Vitro Analysis of Human Serum Albumin Nanoparticles Loaded with Anthracycline Derivatives. Chem Pharm Bull (Tokyo). 66 (4),382-390頁 (共著)
14.	2017/10	論文	Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate. Eur J Pharm Sci. 106,10-19頁 (共著)
15.	2017/09	論文	Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer. Biomaterials. 140,162-169頁 (共著)
16.	2017/04	論文	Hyaluronic Acid-zinc Protoporphyrin IX Conjugates for Photodynamic Antitumor Therapy Journal of Nanomedicine & Nanotechnology (共著)
17.	2016/12	論文	Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin. Mol Pharm. 13 (12),4106-4115頁 (共著)
18.	2016/05	論文	Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect 癌と化学療法 43 (5),549-557頁 (共著)
19.	2016/04	論文	N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-L-tryptophan. Biochem Biophys Rep. 6,266-274頁 (共著)
20.	2016/02	論文	pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect Colloids Surf B Biointerfaces 138,128-137頁 (共著)
21.	2015	論文	HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases. Target Oncol (共著)
22.	2015/08	論文	S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes. J Control Release 217,1-9頁 (共著)
23.	2015/03	論文	Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin. Cancer Sci 106 (3),270-278頁 (共著)
24.	2015/02	論文	Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice. Eur J Pharm Biopharm 90,90-96頁 (共著)
25.	2015/01	論文	Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls. Expert Opin Drug Deliv 12 (1),53-64頁 (共著)
26.	2015/03	論文	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin Future Science OA (共著)
27.	2015/01	論文	Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor Eur J Pharm Biopharm 89,259-270頁 (共著)
28.	2014/10	論文	Enhanced bacterial tumor delivery by modulating the EPR effect and therapeutic potential of Lactobacillus casei J Pharm Sci 103 (10),3235-3243頁 (共著)
29.	2014/08	論文	Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease. J Control Release 187,14-21頁 (共著)
30.	2014/06	論文	EPR効果に基づくポリマー抗癌剤の腫瘍デリバリー　－微小癌の検出・治療を目的としたセラノスティック薬剤の開発－化学工業 65,50 (共著)
31.	2014/01	論文	Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage. J Control Release 174,81-87頁 (共著)
32.	2013/12	論文	Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involve suppression of oxidative stress and inflammatory cytokines. Carcinogenesis 34,2833-2841頁 (共著)
33.	2013	論文	The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo Adv Drug Deliver Rev 65,71-79頁 (共著)
34.	2013	論文	Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo J Control Release 165,191-198頁 (共著)
35.	2013	論文	Characterization of Carotenoid Fatty Acid Esters from the Peels of the Persimmon Diospyros kaki Chem Pharm Bull (Tokyo) 61,666-669頁 (共著)
36.	2013	著書	Cancer Chemotherapy Fundamentals of Pharmaceutical Nanoscience,401-427頁 (共著)
37.	2013/10	論文	PEG化製剤に光明：ABC現象は回避できるか？ファルマシア 49 (10) (単著)
38.	2012	論文	Protective Role of D -Amino Acid Oxidase Against Staphylococcus aureus Infection. Infect Immun 80,1546-1553頁 (共著)
39.	2012	論文	Pegylated D -amino acid oxidase restores bactericidal activity of neutrophils in chronic granulomatous disease via hypochlorite Exp Biol Med 237,703-708頁 (共著)
40.	2012	論文	HSP32 (HO-1) inhibitor, copoly(styrene-maleic acid)-zinc protoporphyrin IX, a water-soluble micelle as anticancer agent: In vitro and in vivo anticancer effect. Eur. J. Pharm. Biopharm 81,540-547頁 (共著)
41.	2012	論文	Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention effect in solid tumors Cancer Sci 103,535-541頁 (共著)
42.	2011	論文	Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model. J Pharmacol Exp Ther 339,779-789頁 (共著)
43.	2011	論文	The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Adv Drug Deliv Rev 63,136-151頁 (共著)
44.	2011	論文	Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles. J Control Release 155,367-375頁 (共著)
45.	2011	論文	4-Amino-6-hydroxypyrazolo [3,4-d]pyrimidine (AHPP) conjugated PEG micelles : water soluble polymeric xanthine oxidase inhibitor. J Drug Target 19,954-966頁 (共著)
46.	2009	論文	SMA-copolymer conjugate of AHPP: a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect. J Control Release 135,211-217頁 (共著)
47.	2008	論文	Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib. Blood 111,2200-2210頁 (共著)
48.	2008	論文	Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase. Int J Cancer 122,1135-1144頁 (共著)
49.	2007	論文	Tumor-targeted induction of oxystress for cancer therapy. J Drug Target 15,475-486頁 (共著)
50.	2006	論文	SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor. Biochem Biophys Res Commun 348,880-888頁 (共著)
51.	2005	論文	SUMO コードの謎を解く実験医学 23,1229-1234頁 (共著)
52.	2005	論文	Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells. FEBS Lett 579,2811-2816頁 (共著)