Faculty Information - Shuto Keiko

Shuto Keiko

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2026/07	Papers	Viral dsRNA drives hyperinflammatory but blunted antiviral responses with enhanced PD-L1 induction in a COPD-like airway epithelial model Biochemistry and Biophysics Reports 47 (Co-authored)
2.	2026/07	Papers	Increased Interleukin-17C Production by the Toll-Like Receptor 3 Ligand Poly(I:C) in Primary Cystic Fibrosis Airway Epithelial Cells Biological and Pharmaceutical Bulletin 49 (7),pp.1194-1203 (Co-authored)
3.	2026/03	Papers	MUC1 and SIGIRR as negative regulators of TLR signaling: Expression, function, and anti-inflammatory augmentation,pp.165-172 (Sole-authored)
4.	2022/07	Papers	A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells International Journal of Molecular Sciences 23 (14),pp.7748 (Co-authored)
5.	2022/03	Papers	Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases Journal of Pharmacological Sciences 149 (2),pp.37-45 (Co-authored)
6.	2020/05	Papers	Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor Against Pathophysiological Decline of Lung Function Antioxidants 9 (5),pp.387 (Co-authored)
7.	2020/04	Papers	Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases Biochemical and Biophysical Research Communications 524 (2),pp.332-339 (Co-authored)
8.	2020/01	Papers	Azithromycin inhibits constitutive airway epithelial sodium channel activation in vitro and modulates downstream pathogenesis in vivo Biological and Pharmaceutical Bulletin 43 (4),pp.725-730 (Co-authored)
9.	2019/03	Papers	Curcumin down-regulates toll-like receptor-2 gene expression and function in human cystic fibrosis bronchial epithelial cells Biological and Pharmaceutical Bulletin 42 (3),pp.489-495 (Co-authored)
10.	2019/02	Papers	Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation Biochemical and Biophysical Research Communications 509 (2),pp.521-528 (Co-authored)
11.	2018/11	Other	Smoking Status Among Pharmacy Students and the Environment that They Started Smoking Journal of Kyushu Pharmacy,pp.7-11 (Co-authored)
12.	2018/01	Papers	Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells EBioMedicine 27,pp.304-316 (Co-authored)
13.	2014/06	Papers	Lipopolysaccharide Decreases Single Immunoglobulin Interleukin-1Receptor-Related Molecule (SIGIRR) Expression by Suppressing Sp1 via TLR4-p38 pathway in monocytes and neutrophils Journal of Biological Chemistry 289 (26),pp.18097-18109 (Co-authored)
14.	2012/04	Papers	Synergism between Interleukin-17 and Toll-like receptor 2 and 4 Signals to Induce IL-8 Expression in Cystic Fibrosis Airway Epithelial Cells Journal of Pharmacological Sciences 118 (4),pp.512-520 (Co-authored)
15.	2009/11	Papers	Calreticulin positively regulates the expression and function of epithelial sodium channel. Experimental Cell Research 315 (19),pp.3294-3300 (Co-authored)
16.	2008/03	Papers	MUC1 mucin is a negative regulator of toll-like receptor signaling American Journal of Respiratory Cell and Molecular Biology 38,pp.263-268 (Co-authored)
17.	2008/01	Papers	Phosphatidic acid metabolism regulates the intracellular trafficking and retrotranslocation of CFTR Biochimica et Biophysica Acta 1783 (1),pp.153-162 (Co-authored)
18.	2006/05	Papers	Calreticulin negatively regulates the cell surface expression of cystic fibrosis transmembrane conductance regulator Journal of Biological Chemistry 281 (18),pp.12841-12848 (Co-authored)
19.	2004/08	Papers	Characterization of the trafficking pathway of cystic fibrosis transmembrane conductance regulator in baby hamster kidney cells Journal of Pharmacological Sciences 95 (4),pp.471-475 (Co-authored)