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FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
> Shuto Keiko
（Last updated : 2026-09-01 09:28:52）
Shuto Keiko
Department / Course
FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
Job
Achievement
Book and thesis
Academic conference presentation
Academic background
Business career
researchmap Researcher code
Research topic, funded research, and department laboratory expense
E-Mail Address
Present specialized field
Department laboratory expense researcher number
Book and thesis
1.
2026/07
Papers
Viral dsRNA drives hyperinflammatory but blunted antiviral responses with enhanced PD-L1 induction in a COPD-like airway epithelial model Biochemistry and Biophysics Reports 47 (Co-authored)
2.
2026/07
Papers
Increased Interleukin-17C Production by the Toll-Like Receptor 3 Ligand Poly(I:C) in Primary Cystic Fibrosis Airway Epithelial Cells Biological and Pharmaceutical Bulletin 49 (7),pp.1194-1203 (Co-authored)
3.
2026/03
Papers
MUC1 and SIGIRR as negative regulators of TLR signaling: Expression, function, and anti-inflammatory augmentation,pp.165-172 (Sole-authored)
4.
2022/07
Papers
A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells International Journal of Molecular Sciences 23 (14),pp.7748 (Co-authored)
5.
2022/03
Papers
Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases Journal of Pharmacological Sciences 149 (2),pp.37-45 (Co-authored)
Display All（19）
Academic conference presentation
1.
2024/10
HDAC3 inhibition enhances IL-37-dependent anti-Inflammatory pathway via SIGIRR/IL-18Rα up-regulation (18th Young Investigator Symposium on Clinical Pharmaceutical Science)
2.
2017/02
Poly(I:C)-dependent anti-inflammatory IL-37b-SIGIRR negative feedback loop is defective in cystic fibrosis airway epithelial cells (15th Cytokines & Inflammation)
3.
2013/09
Lipopolysaccharide decreases SIGIRR expression by suppressing Sp1 via TLR4-p38 MAP kinase pathway in monocytes and neutrophils (Cytokines 2013)
4.
2013/09
Increased IL-17C production by TLR3 Ligand Poly(I:C) in Primary Cystic Fibrosis Airway Epithelial Cells (Cytokines 2013)
Academic background
1.
2000/04～2004/03
Faculty of Pharmaceutical Science Kumamoto University Graduated
2.
2004/04～2006/03
Master Graduate School, Division of Pharmaceutical Sciences Kumamoto University Finished
3.
2006/04～2009/03
Doctorial Graduate School, Division of Pharmaceutical Sciences Kumamoto University Finished
Business career
1.
2008/04/01 ～ 2010/03/31
SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2.
2010/04/01 ～ 2018/03/31
SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
researchmap Researcher code
B000346847
Research topic, funded research, and department laboratory expense
1.
2019/04 ～ 2022/03
Elucidation of the regulation mechanism of cystic fibrosis-specific splice variant expression and development of novel therapeutic strategies Grant-in-Aid for Scientific Research (C)
2.
2016/04 ～ 2019/03
Therapeutic application to cystic fibrosis based on IL-37 and stabilized cell surface expression of SIGIRR Grant-in-Aid for Scientific Research（C）
3.
2014/04 ～ 2016/03
Molecular basis of SIGIRR expression and regulatory function in Cystic Fibrosis and its therapeutic approach Grant-in-Aid for Young Scientists（B）
E-Mail Address
Present specialized field
Biological pharmacy
Department laboratory expense researcher number
70510692
