■ Book and thesis
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1.
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2022
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Article
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Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells. The Journal of toxicological sciences 47(9),pp.381-387 (Collaboration)
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2.
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2022
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Article
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Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4. Frontiers in pharmacology 13,pp.832931 (Collaboration)
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3.
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2021/04
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Article
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LAPTM4a is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins. Biochem. Biophys. Res. Commun. 556,pp.9-15 (Collaboration)
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4.
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2021/09
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Article
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DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis. Scientific reports 11(1),pp.18532 (Collaboration)
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5.
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2021
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Article
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Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products. The Journal of toxicological sciences 46(11),pp.509-514 (Collaboration)
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6.
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2021
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Article
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Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences. Biological & pharmaceutical bulletin 44(11),pp.1635-1644 (Collaboration)
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7.
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2020
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Article
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The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. J. Toxicol. Sci. 45(7),pp.401-409 (Collaboration)
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8.
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2020/10
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Article
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The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9. Drug metabolism and pharmacokinetics 35(5),pp.466-474 (Collaboration)
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9.
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2020/04
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Article
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Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells. Bioscience Reports 40(4) (Collaboration)
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10.
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2020/04
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Article
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Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT. Biochemical and Biophysical Research Communications 525(2),pp.348-353 (Collaboration)
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11.
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2020/03
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Article
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UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression. British Journal of Pharmacology 177(5),pp.1077-1089 (Collaboration)
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12.
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2019/10
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Article
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Advantage of a co-expression system for estimating physiological effects of functional interaction between cytochrome P450 3A4 and uridine 5’-diphospho-glucuronosyltransferase 2B7. BPB Reports 2(5),pp.61-6 (Collaboration)
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13.
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2019/05
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Article
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Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants. Molecular Pharmacology 95(5),pp.551-562 (Collaboration)
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14.
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2017/12
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Article
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Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal. Cellular Signalling 40,pp.200-209 (Collaboration)
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15.
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2017/05
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Article
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Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation. The Journal of Pharmacology and Experimental Therapeutics 361(2),pp.199-208 (Collaboration)
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16.
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2016
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Article
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Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation. Frontiers in Pharmacology 7,pp.427 (Collaboration)
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17.
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2015/10
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Article
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Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region. Molecular pharmacology 88(4),pp.800-12 (Collaboration)
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18.
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2012
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Article
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Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols. Biological & pharmaceutical bulletin 35(10),pp.1811-7 (Collaboration)
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Display 5 items
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Display all(18)
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■ Academic background
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■ Business career
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■ Belonging society
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1.
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2019/03～
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International Society for Study of Xenobiotics
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2.
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2021/04～
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American Society for Pharmacology and Experimental Therapeutics
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■ Research topic, funded research, and department laboratory expense
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■ Home Page
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■ Research Field
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■ Present specialized field
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Health Science, Toxicology
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■ Department laboratory expense researcher number
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