Faculty Information - Ikeda Tsuyoshi

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Book and thesis

Academic conference presentation

Business career

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Present specialized field

Acquisition patent

（Last updated : 2020-05-29 10:26:28）

Ikeda Tsuyoshi
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES

Position

■ Book and thesis

1.	2019/07	Article	A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis. Bioscience, biotechnology, and biochemistry 83(7),pp.1382-1384 (Collaboration)
2.	2018/08	Article	Rapid bactericidal action of propolis on Porphyromonas gingivalis Journal of Dental Research 97(8),pp.928-936 (Collaboration)
3.	2018/08	Article	Self-assembly of [Au(CN)2]- complexes with tomato (Solanum lycopersicum) steroidal alkaloid glycosides to form sheet or tubular structures Chemistry Letters 47(8),pp.1010-1013 (Collaboration)
4.	2017/02	Article	Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenylated flavonoids J. Periodontal Res. 52(1),pp.89-96 (Collaboration)
5.	2005/05	Article	A new tomato pregnane glycoside from the overripe fruits. Chemical & pharmaceutical bulletin 53(5),pp.584-5 (Collaboration)
6.	2005/07	Article	Tomato new sapogenols, isoesculeogenin A and esculeogenin B. Chemical & pharmaceutical bulletin 53(7),pp.839-40 (Collaboration)
7.	2005/09	Article	Anti-herpes virus type 1 activity of oleanane-type triterpenoids. Biological & pharmaceutical bulletin 28(9),pp.1779-81 (Collaboration)
8.	2005/09	Article	New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis. Chemical & pharmaceutical bulletin 53(9),pp.1175-7 (Collaboration)
9.	2005/09	Article	Three unusual 22-beta-O-23-hydroxy-(5 alpha)-spirostanol glycosides from the fruits of Solanum torvum. Chemical & pharmaceutical bulletin 53(9),pp.1122-5 (Collaboration)
10.	2005/10	Article	Iridoid glucosides from the fruit of Genipa americana. Chemical & pharmaceutical bulletin 53(10),pp.1342-4 (Collaboration)
11.	2006	Article	Chemical Trans-Glycosylation of Bioactive Glycolinkage: Synthesis of an α-Lycotetraosly Cholesterol. Tetrahedron Lett. 47,pp.4355-4359 (Collaboration)
12.	2006/02	Article	Steroidal alkaloid glycosides, esculeosides C and D, from the ripe fruit of cherry tomato. Chemical & pharmaceutical bulletin 54(2),pp.237-9 (Collaboration)
13.	2006/02	Article	Steroidal glycosides from the underground parts of Solanum sodomaeum. Chemical & pharmaceutical bulletin 54(2),pp.230-3 (Collaboration)
14.	2006/09	Article	Metabolism of tomato steroidal glycosides in humans. Chemical & pharmaceutical bulletin 54(9),pp.1312-4 (Collaboration)
15.	2006/10	Article	Acyclic diterpene glycosides, capsianosides VIII, IX, X, XIII, XV and XVI from the fruits of Paprika Capsicum annuum L. var. grossum BAILEY and Jalapeño Capsicum annuum L. var. annuum. Chemical & pharmaceutical bulletin 54(10),pp.1365-9 (Collaboration)
16.	2006/10	Article	Cucurbitane glycosides from unripe fruits of Lo Han Kuo (Siraitia grosvenori). Chemical & pharmaceutical bulletin 54(10),pp.1425-8 (Collaboration)
17.	2006/10	Article	New iridoid glucosides from the aerial parts of Verbena brasiliensis. Chemical & pharmaceutical bulletin 54(10),pp.1421-4 (Collaboration)
18.	2006/10	Article	Steroidal glycosides and aromatic compounds from Smilax riparia. Chemical & pharmaceutical bulletin 54(10),pp.1451-4 (Collaboration)
19.	2007/04	Article	Three new monoterpenoids from the fruit of Genipa americana. Chemical & pharmaceutical bulletin 55(4),pp.632-4 (Collaboration)
20.	2007/04	Article	Two new steroid glycosides and a new sesquiterpenoid glycoside from the underground parts of Trillium kamtschaticum. Chemical & pharmaceutical bulletin 55(4),pp.551-6 (Collaboration)
21.	2007/07	Article	alpha-Tomatine, the major saponin in tomato, induces programmed cell death mediated by reactive oxygen species in the fungal pathogen Fusarium oxysporum. FEBS letters 581(17),pp.3217-22 (Collaboration)
22.	2007/07	Article	Cucurbitane glycosides from unripe fruits of Siraitia grosvenori. Chemical & pharmaceutical bulletin 55(7),pp.1082-6 (Collaboration)
23.	2007/07	Article	Distinction of absolute configuration at C-22 of C-23-hydroxyspirostane and C-23-hydroxyspirosolane glycosides. Chemical & pharmaceutical bulletin 55(7),pp.1079-81 (Collaboration)
24.	2007/07	Article	Efficient conversion of tomatidine into neuritogenic pregnane derivative. Chemical & pharmaceutical bulletin 55(7),pp.1077-8 (Collaboration)
25.	2007/07	Article	Three new steroid glycosides from the underground parts of Trillium kamtschaticum. Chemical & pharmaceutical bulletin 55(7),pp.1093-6 (Single)
26.	2007/08	Article	Acyclic diterpene glycosides, capsianosides C, D, E, F and III, from the fruits of hot red pepper Capsicum annuum L. used in Kimchi and their revised structures. Chemical & pharmaceutical bulletin 55(8),pp.1151-6 (Collaboration)
27.	2007/08	Article	Iridoids from the green leaves of Eucommia ulmoides Journal of natural products 70(8),pp.1312-6 (Collaboration)
28.	2007/11	Article	Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT. Arteriosclerosis, thrombosis, and vascular biology 27(11),pp.2400-6 (Collaboration)
29.	2007/11	Article	Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety. Carbohydrate research 342(15),pp.2182-91 (Collaboration)
30.	2008/01	Article	DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla. Journal of natural medicines 62(1),pp.101-6 (Collaboration)
31.	2008/01	Article	Two new lignan glucosides from the fruit of Vitex cannabifolia. Journal of natural medicines 62(1),pp.47-51 (Collaboration)
32.	2008/04	Article	Some natural compounds enhance N epsilon-(carboxymethyl)lysine formation. Annals of the New York Academy of Sciences 1126,pp.152-4 (Collaboration)
33.	2008/04	Article	Three new acyclic diterpene glycosides from the aerial parts of paprika and pimiento. Chemical & pharmaceutical bulletin 56(4),pp.582-4 (Collaboration)
34.	2008/04	Article	Usefulness of antibodies for evaluating the biological significance of AGEs. Annals of the New York Academy of Sciences 1126,pp.38-41 (Collaboration)
35.	2008/06	Article	Efficient synthesis of alpha- and beta-chacotriosyl glycosides using appropriate donors, and their cytotoxic activity. Carbohydrate research 343(8),pp.1309-15 (Collaboration)
36.	2008/07	Article	A new homostilbene and two new homoisoflavones from the bulbs of Scilla scilloides. Chemical & pharmaceutical bulletin 56(7),pp.1022-5 (Collaboration)
37.	2008/07	Article	A pregnane glycoside from overripe tomato. Chemical & pharmaceutical bulletin 56(7),pp.1013-4 (Collaboration)
38.	2008/07	Article	Conversion of esculeoside A into esculeogenin B. Chemical & pharmaceutical bulletin 56(7),pp.926-9 (Collaboration)
39.	2008/07	Article	Mechanism for conversion of spirosolane derivative into pregnane. Chemical & pharmaceutical bulletin 56(7),pp.1015-7 (Collaboration)
40.	2008/07	Article	New C(28) steroidal glycosides from Tubocapsicum anomalum. Chemical & pharmaceutical bulletin 56(7),pp.1038-40 (Collaboration)
41.	2008/08	Article	Studies on the constituents of Gueldenstaedtia multiflora. Chemical & pharmaceutical bulletin 56(8),pp.1138-42 (Collaboration)
42.	2008/10	Article	A new steroidal glycoside and a new phenyl glycoside from a ripe cherry tomato. Chemical & pharmaceutical bulletin 56(10),pp.1499-501 (Collaboration)
43.	2008/11	Article	Five new diterpenoids, viteagnusins A--E, from the fruit of Vitex agnus-castus. Chemical & pharmaceutical bulletin 56(11),pp.1621-4 (Collaboration)
44.	2009/01	Article	A new lignan glucoside from the stems of Callicarpa japonica Thunb. var. luxurians Rehd. Journal of natural medicines 63(1),pp.86-90 (Collaboration)
45.	2009/04	Article	Involvement of ethylene in the accumulation of esculeoside A during fruit ripening of tomato (Solanum lycopersicum). Journal of agricultural and food chemistry 57(8),pp.3247-52 (Collaboration)
46.	2009/06	Article	Steroidal glycosides from the fruits of Solanum viarum. Chemical & pharmaceutical bulletin 57(6),pp.632-5 (Collaboration)
47.	2009/07	Article	Five new steroidal glycosides from the stems of Solanum sodomaeum. Chemical & pharmaceutical bulletin 57(7),pp.759-63 (Collaboration)
48.	2009/07	Article	Studies on the constituents of whole plants of Youngia japonica. Chemical & pharmaceutical bulletin 57(7),pp.719-23 (Collaboration)
49.	2009/07	Article	Two new acyclic diterpene glycosides from fruits of Habanero, Capsicum chinense. Chemical & pharmaceutical bulletin 57(7),pp.730-3 (Collaboration)
50.	2009/08	Article	Two new cucurbitane-type glycosides obtained from roots of Siraitia grosvenori SWINGLE. Chemical & pharmaceutical bulletin 57(8),pp.870-2 (Collaboration)
51.	2009/10	Article	Three new diterpenoids from the fruit of Vitex agnus-castus. Chemical & pharmaceutical bulletin 57(10),pp.1132-5 (Collaboration)
52.	2010/06	Article	Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor. Bioorganic & medicinal chemistry letters 20(11),pp.3341-3 (Collaboration)
53.	2010/07	Article	Onionin A from Allium cepa inhibits macrophage activation. Journal of natural products 73(7),pp.1306-8 (Collaboration)
54.	2010/08	Article	HSP70 inducers from Chinese herbs and their effect on melanin production. Experimental dermatology 19(8),pp.e340-2 (Collaboration)
55.	2010/08	Article	Notoamide O, a structurally unprecedented prenylated indole alkaloid, and notoamides P-R from a marine-derived fungus, Aspergillus sp. Journal of natural products 73(8),pp.1438-40 (Collaboration)
56.	2010/10	Article	Study of constituents of Veronicastrum villosulum. Journal of natural medicines 64(4),pp.510-3 (Collaboration)
57.	2010/10	Article	The tomato saponin, esculeoside A. Journal of natural products 73(10),pp.1734-41 (Collaboration)
58.	2010/10	Article	Three new aromatic glycosides from the ripe fruit of cherry tomato. Journal of natural medicines 64(4),pp.500-5 (Collaboration)
59.	2010/11	Article	Acylated glycosides of hydroxy fatty acid methyl esters generated from the crude resin glycoside (pharbitin) of seeds of Pharbitis nil by treatment with indium(III) chloride in methanol. Journal of natural products 73(11),pp.1846-52 (Collaboration)
60.	2011	Article	Anti-obesity compounds in green leaves of Eucommia ulmoides. Bioorg. Med. Chem. Lett. 21,pp.1786-1791
61.	2011	Article	Four new iridoid glucosides from Ajuga reptans. Chemical & pharmaceutical bulletin 59(8),pp.1065-8 (Collaboration)
62.	2011	Article	Garlicnin A from the fraction regulating macrophage activation of Allium sativum. Chemical & pharmaceutical bulletin 59(11),pp.1340-3 (Collaboration)
63.	2011	Article	Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor. Chemical & pharmaceutical bulletin 59(2),pp.287-90 (Collaboration)
64.	2011/01	Article	Content variations of the tomato saponin esculeoside A in various processed tomatoes. Journal of natural medicines 65(1),pp.176-9 (Collaboration)
65.	2011/01	Article	Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. Cancer science 102(1),pp.206-11 (Collaboration)
66.	2011/01	Article	Study of the chemical constituents of Pruni Cortex and its related parts. Journal of natural medicines 65(1),pp.166-71 (Collaboration)
67.	2011/04	Article	Changes in esculeoside A content in different regions of the tomato fruit during maturation and heat processing. Journal of agricultural and food chemistry 59(8),pp.4104-10 (Collaboration)
68.	2011/04	Article	Lucidenic acids-rich extract from antlered form of Ganoderma lucidenhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK. Biochemical and biophysical research communications 408(1),pp.18-24 (Collaboration)
69.	2011/04	Article	Natural compounds containing a catechol group enhance the formation of Nε-(carboxymethyl)lysine of the Maillard reaction. Free radical biology & medicine 50(7),pp.883-91 (Collaboration)
70.	2011/05	Article	Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages. Journal of agricultural and food chemistry 59(9),pp.4544-52 (Collaboration)
71.	2011/12	Article	Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. Oncology reports 26(6),pp.1533-7 (Collaboration)
72.	2012	Article	Garlicnins B(1), C(1), and D, from the fraction regulating macrophage activation of Allium sativum. Chemical & pharmaceutical bulletin 60(6),pp.747-51 (Collaboration)
73.	2012/03	Article	Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT). Journal of agricultural and food chemistry 60(10),pp.2472-9 (Collaboration)
74.	2012/04	Article	Purification and characterization of HSP-inducers from Eupatorium lindleyanum. Biochemical pharmacology 83(7),pp.909-22 (Collaboration)
75.	2013	Article	Identification and Biological Activity of Antifungal Saponins from Shallot (Allium cepa L. Aggregatum Group) Journal of Agricultural and Food Chemistry 61(31),pp.7440-7445 (Collaboration)
76.	2013	Article	The Chemistry and Bioactivity of Eucommia ulmoides Oliver Leaves Study in Natural Product Chemistry (Collaboration)
77.	2013/04	Article	Aginoside saponin, a potent antifungal compound, and secondary metabolite analyses from Allium nigrum L. Phytochemistry Letters 6(2),pp.274-280 (Collaboration)
78.	2013/04	Article	Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) against ATL cell lines and structure-activity relationships with withanolides isolated from solanaceous plants. Journal of natural medicines 67(2),pp.415-20 (Collaboration)
79.	2013/06	Article	Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells. Molecular nutrition & food research 57(6),pp.1046-54 (Collaboration)
80.	2013/07	Article	Cyclic sulfoxides garlicnins B2, B3, B4, C2, and C3 from Allium sativum. Chemical & pharmaceutical bulletin 61(7),pp.695-9 (Collaboration)
81.	2013/07	Article	Saponins esculeosides B-1 and B-2 in Italian canned tomatoes. Chemical & pharmaceutical bulletin 61(7),pp.764-7 (Collaboration)
82.	2013/08	Article	Identification and biological activity of antifungal saponins from shallot ( Allium cepa L. Aggregatum group). Journal of agricultural and food chemistry 61(31),pp.7440-5 (Collaboration)
83.	2013/12	Article	Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. Oncology letters 6(6),pp.1619-1623 (Collaboration)
84.	2014	Article	Acyclic sulfides, garlicnins L-1-L-4, E, and F, from Allium sativum. Chemical & pharmaceutical bulletin 62(5),pp.477-82 (Collaboration)
85.	2014/05	Article	Conversion of tomato saponins to pregnane derivatives. Chemical & pharmaceutical bulletin 62(5),pp.483-7 (Collaboration)
86.	2014/11	Article	Isolation and characterization of new onionins A2 and A3 from Allium cepa, and of onionins A1, A2, and A3 from Allium fistulosum. Chemical & pharmaceutical bulletin 62(11),pp.1141-5 (Collaboration)
87.	2015	Article	Saponins, Esculeosides B-1 and B-2, in Tomato Juice and Sapogenol, Esculeogenin B1. Chemical & pharmaceutical bulletin 63(10),pp.848-50 (Collaboration)
88.	2015/02	Article	A new hemiterpene glycoside from the ripe tomatoes. Natural product research 29(3),pp.262-7 (Collaboration)
89.	2015/04	Article	Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers. Journal of dermatological science 78(1),pp.67-75 (Collaboration)
90.	2016/04	Article	Two new bicyclic sulfoxides from Welsh onion. Journal of natural medicines 70(2),pp.260-5 (Collaboration)
91.	2016/04	Article	Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products. Journal of natural medicines 70(2),pp.290-5 (Collaboration)
92.	2016/06	Article	Eucommia ulmoides extracts prevent the formation of advanced glycation end products. Food & Function 7(6),pp.2566-2573 (Collaboration)
93.	2016/06	Article	Eucommia ulmoides extracts prevent the formation of advanced glycation end products. Food & function 7(6),pp.2566-73 (Collaboration)
94.	2016/07	Article	Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages. Scientific reports 6,pp.29588 (Collaboration)
95.	2016/10	Article	Antimicrobial and immunomodulatory activities of flavonol glycosides isolated from Atriplex halimus L. herb Journal of Pharmaceutical Sciences and Research 8(10),pp.1159-1168 (Collaboration)
96.	2016/11	Article	Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells. Molecular nutrition & food research 60(11),pp.2467-2480 (Collaboration)
97.	2017	Article	Antitumor Allium Sulfides. Chemical & pharmaceutical bulletin 65(3),pp.209-217 (Collaboration)
98.	2017	Article	Atypical Cyclic Sulfides, Garlicnins G, I, and J, Extracted from Allium sativum. Chemical & pharmaceutical bulletin 65(1),pp.102-106 (Collaboration)
99.	2017/03	Article	Antitumor Allium sulfides Chemical & Pharmaceutical Bulletin 65(3),pp.209-217 (Collaboration)
100.	2017/09	Article	Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition. Nitric oxide : biology and chemistry 69,pp.28-34 (Collaboration)
101.	2018/01	Article	Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation. Journal of clinical and experimental hematopathology : JCEH 58(1),pp.17-23 (Collaboration)
102.	2018/01	Article	New cyclic sulfides extracted from Allium sativum: garlicnins P, J2, and Q. Journal of natural medicines 72(1),pp.335-341 (Collaboration)
103.	2018/01	Article	New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum. Journal of natural medicines 72(1),pp.326-331 (Collaboration)
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■ Academic conference presentation

2015/11/02

Prenylated Flavonoids from Epimedii Herba Inhibits the Formation of Advanced Glycation End-products. (International Conference on Conservation of Biodiversity and Sustainable Use of Tropical and Subtropical Plants)

■ Business career

1.	2014/04～	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2.	2011/04～2014/03	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
3.	2012/04～	/(DC)Division of Pharmaceutical Sciences
4.	1998/04～2002/04	Assistant Professor

■ researchmap Researcher code

1000222598

■ Present specialized field

Environmental and natural pharmaceutical resources, Pharmaceutical chemistry and drug development sciences

■ Acquisition patent

1.	2013/07/09	3-(Aminocarbonyl)-1-[5-O-[[1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranos-5-O-yl]phosphonyloxy(oxylato)phosphinyl]-β-L-ribofuranosyl]pyridinium, its preparation, and axon elongation and neurite outgrowth promoter, antitumor agent, and food containing it
2.	2014/04/02	Phenylpropanoid compound having deodorizing activity

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