Faculty Information - Kuniyasu Akihiko

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Book and thesis

Academic conference presentation

Academic background

Business career

Belonging society

Research topic, funded research, and department laboratory expense

E-Mail Address

Present specialized field

Department laboratory expense researcher number

（Last updated : 2022-04-07 15:08:34）

Kuniyasu Akihiko
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES

Position

■ Book and thesis

1.	1996	Article	Identification of binding sites for calcium channel antagonists. Jpn. Heart J. 37,,pp.643-650 (Collaboration)
2.	1998	Article	Photochemical identification of transmembrane segment IVS6 as the binding region of semotiadil, a new modulator for the L-type voltage-dependent Ca2+ channel. J. Biol. Chem. 273,pp.4635-4641 (Collaboration)
3.	1999	Article	[³⁵S] S-[5-(4-benzoylphenyl) pentyl] glutathione: a versatile radioligand targeting GS-X pumps with the ability of photoaffinity labeling. Bioorg. Med. Chem. Lett. 9,pp.2661-2666 (Collaboration)
4.	1999	Article	A new scorpion toxin (BmK-PL) stimulates Ca²⁺-release channel activity of the skeletal-muscle ryanodine receptor by an indirect mechanism. Biochem. J. 339,pp.343-350 (Collaboration)
5.	2000	Article	Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme. Biochem. Biophys. Res. Commun. 277,pp.417-422 (Collaboration)
6.	2001	Article	Asymmetric arrangement of auxiliary subunits of skeletal muscle voltage-gated L-type Ca²⁺ channel. Biochem. Biophys. Res. Commun. 282,pp.284-291 (Collaboration)
7.	2001	Article	Co-induction of arginino- succinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells. Brain Res. Mol. Brain Res. 90,pp.165-173 (Collaboration)
8.	2002	Article	Adipocytes recognize and degrade oxidized low density lipoprotein through CD36. Biochem. Biophys. Res. Commun. 295,pp.319-323 (Collaboration)
9.	2002	Article	Efficient identification of photolabelled amino acid residues by combining immunoaffinity purification with MS: revealing the semotiadil-binding site and its relevance to binding sites for myristates in domain III of human serum albumin Biochem. J. 363,pp.223-232 (Collaboration)
10.	2003	Article	Advanced glycation end products (AGE) inhibit scavenger receptor class B type I-mediated reverse cholesterol transport: a new crossroad of AGE to cholesterol metabolism. J. Atheroscler. Thromb. 10,pp.1-6 (Collaboration)
11.	2003	Article	CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes. FEBS Lett. 537,pp.85-90 (Collaboration)
12.	2003	Article	Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductase. Chem. Biol. Interact. 143-144,pp.353-361 (Collaboration)
13.	2003	Article	Molecular assembly and subcellular distribution of ATP-sensitive potassium channel proteins in rat hearts. FEBS Lett. 552,pp.259-263 (Collaboration)
14.	2003	Article	Photochemical identification of the binding region for (S)-semotiadil on sodium channels: comparison with that for (R)-semotiadil on skeletal muscle calcium channel. Heterocycles 59,pp.613-622 (Collaboration)
15.	2004	Article	Advanced glycation end products- modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36. Biochem. Biophys. Res. Commun. 325,pp.151-156 (Collaboration)
16.	2005	Article	Characterization of benzodiazepine binding site on human a1-acid glycoprotein using flunitrazepam as a photolabeling agent. Biochim. Biophys. Acta 1725,pp.385-393 (Collaboration)
17.	2005	Article	Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na⁺ channel blocker aprindine. Biochem. Biophys. Res. Commun. 331,pp.1001-1006 (Collaboration)
18.	2005	Article	Stoichiometry and binding site analysis of ligand-human serum albumin complex by photoaffinity labeling and mass spectrometry. J. Mass Spectrom. Soc. Jpn. 53,pp.18-24 (Collaboration)
19.	2006	Article	Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries. Cancer Res. 66,pp.34-40 (Collaboration)
20.	2007	Article	A previously unrecognized protein-protein interaction between TWEAK and CD163: Potential biological implications. J. Immunol. 178,pp.8183-8194 (Collaboration)
21.	2008	Article	Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells. J. Biol. Chem. 283,pp.11752-11762 (Collaboration)
22.	2008	Article	Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells. Pharm. Res. 25,pp.827-835 (Collaboration)
23.	2009	Article	A synthetic approach to develop peptide inhibitors selective for brain-type sodium channels on the basis of pompilidotoxin structure. Heterocycles 79,pp.925-933 (Collaboration)
24.	2009	Article	Linkage between phosphorylation of the origin recognition complex and its ATP-binding activity in Saccharomyces cerevisiae. J. Biol. Chem. 284,pp.3396-3407 (Collaboration)
25.	2009	Article	Marked induction of inducible nitric oxide synthase and tumor necrosis factor-α in rat CD40⁺ microglia by comparison to CD40 microglia. J. Neuroimmunol. 208,pp.70-79 (Collaboration)
26.	2009	Article	Oral administration of synthetic retinoid Am80(Tamibarotene) decreases brain β-amyloid peptides in APP23 mice. Biol. Pharm. Bull. 32,pp.1307-1309 (Collaboration)
27.	2010	Article	Contribution of BCR-ABL-independent activation of ERK1/2 to acquired imatinib resistance in K562 chronic myeloid leukemia cells. Cancer Sci. 101,pp.137-142 (Collaboration)
28.	2010	Article	Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5_a receptor by a single amino acid substitution. J. Leukoc. Biol. 87,pp.965-975 (Collaboration)
29.	2010	Article	Three-dimensional structure of α1-β complex in skeletal muscle dihydropyridine receptor by single particle electron microscopy. J. Electron Microsc. 59,pp.215-226 (Collaboration)
30.	2010/02	Article	Notch-1 fragment peptide induces autophagy and caspase-independent cell death in leukemia cell lines An AACR special conference series: Cell Death Mechanisms and Cancer Therapy pp.71 (Collaboration)
31.	2010/10	Article	Cell-selective cell penetrating peptide as an intelligent molecular carrier BIT 1st Annual World Congress of NanoMedicine-2010 (Collaboration)
32.	2011	Article	Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1/2 activation in 3T3-L1 adipocytes. Biochim. Biophys. Acta 1811,pp.153-162 (Collaboration)
33.	2011	Article	Quantitative analysis of cysteine-34 on the aniti-oxidative properties of human serum albumin in hemodialysis patients J. Pharm. Sci. 100,pp.3968-3976 (Collaboration)
34.	2011	Article	Targeting neuropilin-1 in human leukemia and lymphoma. Blood 117,pp.920-927 (Collaboration)
35.	2012	Article	Effects of C4_a on chemoattractant and secretagogue functions of the other anaphylatoxins via Gi protein-adenylyl cyclase inhibition pathway in mast cells. Int. Immunopharmacol. 12,pp.158-68 (Collaboration)
36.	2012/02	Article	A hybrid peptide-25mer induces a caspase-independent cell death in leukemic cell lines Cell Death in Cancer pp.21 (Collaboration)
37.	2013	Article	Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 69,pp.45-48 (Collaboration)
38.	2014	Article	Cooperative therapeutic action of retinoic Acid receptor and retinoid X receptor agonists in a mouse model of Alzheimer's disease. J. Alzheimers Dis. 42,pp.587-605 (Collaboration)
39.	2014/07	Article	Hybrid peptide tat-Ram13-induced necrosis-like cell death depends on expression of PTEN in human leukemia cell lines. Eur. J. Cancer 50,pp.23-24 (Collaboration)
40.	2015	Article	Targeting interleukin-11 receptor in leukemia and lymphoma: A functional ligand-directed study and hematopathology analysis of patient-derived specimens. Clin. Cancer Res. 21(13),pp.3041-3051 (Collaboration)
41.	2016/11	Article	The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain. Glia 64(11),pp.1938-1961 (Collaboration)
42.	2017	Book	Combination of Photoaffinity Label and Site-Directed Antibody for Target Proteins Photoaffinity Labeling for Structural Probing Within Protein pp.93-110 (Collaboration)
43.	2018/05	Article	Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery. J Control Release 10(277),pp.23-34 (Collaboration)
44.	2018/05	Article	The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype. BMC Cancer 18(1),pp.519 (Collaboration)
45.	2018/05	Article	Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates. Pharmacogenomics J. 18(3),pp.436-443 (Collaboration)
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■ Academic conference presentation

1.	2010/02/03	Notch-1 Fragment Peptide Induces Autophagy and Caspase-independent Cell Death in Leukemia Cell Lines. (AACR Special Conference: Cell Death Mechanisms and Cancer Therapy)
2.	2015/06/03	Statistical Phase Noise Elimination for Amyloid Plaque Detection (The Joint Annual Meeting ISMRM-ESMRMB)
3.	2015/09/12	A modified iron staining method for formalin-fixed brain section: towords the iron-based amyloid imagings on MRI (The 9th International Congress of the Asian Society Against Dementia)
4.	2015/09/12	Phase difference enhanced imaging (PADRE) as novel non-invasive tool fro amyloid plaque detection (The 9th International Congress of the Asian Society Against Dementia)
5.	2015/09/12	Phase information as a non-invasive tool with high detectability of amyloid plaque. (The 9th International Congress of the Asian Society Against Dementia)
6.	2016/01	The structural basis for the leukemia-specific necrosis induction by the Notch-1-derived peptide fragment (EACR Conference: A Matter of Life or Death)
7.	2016/07	Leukemic cell death induced by the Notch-1 fragment-derived peptide evokes immunogenic inflammation (EACR24)
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■ Academic background

1.	1983/04～1987/03	Faculty of Pharmaceutical Science, Hokkaido University, Graduated,
2.	1987/04～1989/03	〔Master Course〕, Graduate School, Division of Pharmaceutical Sciences, Hokkaido University, Completed,
3.	1990/04～1993/03	〔Doctorial Course〕, Graduate School of Pharmaceutical Sciences, Hokkaido University, Accomplished credits for doctoral program, Ph.D.

■ Business career

1.	2018/05～	The Open University of Japan
2.	2012/04～	/(DC)Division of Pharmaceutical Sciences
3.	2012/04～	Graduate School of Engineering /Division of Applied Chemistry
4.	2011/04～	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
5.	1992/08～1994/12	Research Assistant

■ Belonging society

1.	2013/10～	European Association for Cancer Research
2.	2018/07～	American Chemical Society
3.		American Association for Cancer Research
4.		Society for Neuroscience

■ Research topic, funded research, and department laboratory expense

1.	2011/04～2014/03	Chemical Biology on the hybrid peptide-induce non-apoptotic cell death (Key Word : )
2.	2011/04～2013/03	Development of transplanted cell-tracking system using MRI (Key Word : )
3.	2011/04～2014/03	Elucidation of the structural basis of the excitation and contraction coupling usiing phase-contrast electron cryotomography (Key Word : )
4.	2009/04～2012/03	Development of amyloid^<13> C-MR imaging of the brain at 7T (Key Word : )
5.	2008/04～2010/03	Development of Ligand-guided Manipulation System of the Cell Functions (Key Word : )
6.	2008/04～2011/03	Development of Selective Modulators for Autophagic Cell Death and Novel Chemotherapeutic Strategy for Leukemia (Key Word : )
7.	2008/04～2011/03	Involvement of Oxidized Phospholipids in Aberrant Expression of Adipocytokines (Key Word : )
8.	2007/04～2009/03	Development of a novel Alzheimer's disease drug utilizing neuroprotective action of activated microglia (Key Word : )
9.	2004/04～2007/03	Elucidation of a novel relationship between the oxidative stress-related products and common diseases (Key Word : )
10.	2003/04～2006/03	Investigation of molecular mechanisms for common diseases caused by aging and oxidative stress and development of drug candidates aiming the molecular targets (Key Word : )
11.	2002/04～2005/03	The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy (Key Word : )
12.	1996/04～1998/03	Drug binding in cardiac calcium channels : Identification and its application to drug development (Key Word : )
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■ E-Mail Address

■ Present specialized field

Others, Bio chemistry, Pathological biochemistry

■ Department laboratory expense researcher number

90241348