Faculty Information - Tsukigawa Kenji

■ Book and thesis

1.	2022	Article	Effect of Fatty Acids and Uremic Toxins on the Binding of Nateglinide, an Insulin Secretagogue, to Site II on Human Serum Albumin. Biological & pharmaceutical bulletin 45(6),pp.803-805 (Collaboration)
2.	2022/03	Article	The Nitrated Form of Nateglinide Induces Apoptosis in Human Pancreatic Cancer Cells Through a Caspase-dependent Mechanism. Anticancer research 42(3),pp.1333-1338 (Collaboration)
3.	2022/03	Article	In Vitro and In Vivo Assessment of Atemoya Fruit (Annona atemoya) for Food-Drug Interactions. European journal of drug metabolism and pharmacokinetics 47(2),pp.177-185 (Collaboration)
4.	2022/01	Article	An in-vitro comparative study of the binding of caspofungin and micafungin to plasma proteins. The Journal of pharmacy and pharmacology 74(1),pp.88-93 (Collaboration)
5.	2021/02	Article	Possible Role of Electrolytes on the Formation of Precipitates during the Infusion of Nafamostat Mesilate in Hemodialysis. Biological & pharmaceutical bulletin 44(2),pp.259-265 (Collaboration)
6.	2021/03	Article	Interaction of Benzbromarone with Subdomains IIIA and IB/IIA on Human Serum Albumin as the Primary and Secondary Binding Regions. Molecular pharmaceutics 18(3),pp.1061-1070 (Collaboration)
7.	2021/01	Article	Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin. Pharmaceuticals (Basel, Switzerland) 14(1) (Collaboration)
8.	2017/08	Article	Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate European journal of pharmaceutical sciences 106,pp.10-19 (Collaboration)
9.	2016/12	Article	Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin. Molecular pharmaceutics 13(12),pp.4106-4115 (Collaboration)
10.	2016/04	Article	A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic Therapy--Problems, Solutions, and Prospects. Microcirculation (New York, N.Y. : 1994) 23(3),pp.173-182 (Collaboration)
11.	2016/02	Article	pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect. Colloids and surfaces. B, Biointerfaces 138,pp.128-137 (Collaboration)
12.	2016	Article	Styrene-maleic acid-copolymer conjugated zinc protoporphyrin as a candidate drug for tumor-targeted therapy and imaging. Journal of drug targeting 24(5),pp.399-407 (Collaboration)
13.	2015/03	Article	Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin. Cancer science 106(3),pp.270-278 (Collaboration)
14.	2015/01	Article	Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor. European journal of pharmaceutics and biopharmaceutics 89,pp.259-270 (Collaboration)
15.	2013/02	Article	Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo. Journal of controlled release : official journal of the Controlled Release Society 165(3),pp.191-198 (Collaboration)
16.	2013	Article	Characterization of carotenoid fatty acid esters from the peels of the persimmon Diospyros kaki. Chemical & pharmaceutical bulletin 61(6),pp.666-669 (Collaboration)
17.	2012/03	Article	Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention effect in solid tumors. Cancer science 103(3),pp.535-541 (Collaboration)
18.	2011/12	Article	Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model. The Journal of pharmacology and experimental therapeutics 339(3),pp.779-789 (Collaboration)
19.	2011/11	Article	Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles. Journal of controlled release : official journal of the Controlled Release Society 155(3),pp.367-375 (Collaboration)
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■ Academic conference presentation

1.	2016/10	Comparison of pegylated zinc protoporphyrin with different chemical bonds in stability during blood circulation, drug release by depegylation in tumor tissue, and antitumor effect (第31回年会日本薬物動態学会)
2.	2015/09	Influence of different chemical bonds in pegylation of zinc protoporphyrin on depegylation, cellular uptake, and antitumor activity (The Academy of Pharmaceutical Science and Technology, Japan, Global Education Seminar　2015-1st)
3.	2015/07	Styrene-maleic acid copolymer conjugated pirarubicin , an anticancer nanomedicine with good stability and tumor-targeting property (42th Annual Meeting and Exposition of the Controlled Release Society)
4.	2014/11	Pharmacokinetic properties and antitumor activity of styrene maleic acid copolymer conjugated pirarubicin (第8回次世代を担う若手医療薬科学シンポジウム)
5.	2013/10	Two step tumor-selective action of pirarubicin-conjugated N-(2-hydroxypropyl) methacrylamide copolymer (第72回日本癌学会学術総会)
6.	2013/10	Targeting of SMA-pirarubicine nanomedicine to the metastatic lung cancer: therapeutic effect and imaging (第72回日本癌学会学術総会)
7.	2013/07	EPR effect in metastatic and autochthonous tumor and antimetastatic effect of SMA-pirarubicin (THP) (40th Annual Meeting and Exposition of the Controlled Release Society)
8.	2013/07	Double selective antitumor action of pirarubicin-conjugated N-(2-hydroxypropyl) methacrylamide copolymer (40th Annual Meeting and Exposition of the Controlled Release Society)
9.	2013/03	The EPR effect and beyond for cancer selective drug delivery and imaging (2nd International Conference on Biomaterials Science)
10.	2013/03	Antitumor effect of styrene- maleic acid copolymer (SMA) derivative conjugated pirarubicin (THP) (2nd International Conference on Biomaterials Science)
11.	2012/08	Distinct tumor targeting and fluorescent imaging using nanoparticle based on EPR effect: Toward fluorescent endoscopy (第71回日本癌学会学術総会)
12.	2012/08	Antitumor activity of pirarubicin conjugated HPMA copolymer via acid labile linkage (第71回日本癌学会学術総会)
13.	2012/07	Tumor selective delivery of Zn-Protoporphyrin conjugated hydroxypropylmethacrylamide polymer (HPMA) micelle for imaging and light induced antitumor effect (39th Annual Meeting and Exposition of the Controlled Release Society)
14.	2012/05	The EPR effect as seen by tumor imaging of fluorescent proteins and synthetic nanoparticles (9th International Symposium on Polymer Therapeutics)
15.	2011/07	The importance of cleavage of PEG chains from pegylated zinc protoporphyrin (PEG-ZnPP) by tumor proteases on intracellular uptake (38th Annual Meeting and Exposition of the Controlled Release Society)
16.	2010/07	Intracellular uptake of water-soluble ZnPP micelles (SMA-ZnPP and PEG-ZnPP) and the unique release mechanism of the drug from their micelles (37th Annual Meeting and Exposition of the Controlled Release Society)
17.	2010/07	Effects of pegylation in intracellular uptake and depegylation for drug release in pegylated zinc protoporphyrin (PEG-ZnPP) micelle (37th Annual Meeting and Exposition of the Controlled Release Society)
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■ Academic background

1.	2005/04～2009/03	Faculty of Pharmaceutical Science, Sojo University, Graduated,
2.	2009/04～2011/03	〔Master Course〕, Graduate School, Division of Engineering, Sojo University, Completed,
3.	2011/04～2012/03	〔Doctorial Course〕, Graduate School, Division of Engineering, Sojo University, Unfinished course
4.	2012/04～2016/03	〔Doctorial Course〕, Graduate School, Division of Pharmaceutical Sciences, Sojo University, Completed,

■ Business career

1.	2015/10～2020/03	Kyushu University of Health and Welfare School of Pharmaceutical Sciences, Department of Pharmaceutical Sciences Assistant Professor
2.	2020/04～2022/03	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

■ researchmap Researcher code

B000338039

■ E-Mail Address

■ Present specialized field

Clinical pharmacy (Key Word：Drug Delivery System)

■ Department laboratory expense researcher number

60772027