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    (Last updated : 2022-12-14 14:27:19)
  Shuto Keiko
   Department   SOJO UNIVERSITY  Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES
   Position  
■ Book and thesis
1. 2022/07 Article A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells International Journal of Molecular Sciences 23(14),pp.7743 (Collaboration) 
2. 2022/06 Article Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases Journal of Pharmacological Sciences 149(2),pp.37-45 (Collaboration) 
3. 2020/05 Article Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor Against Pathophysiological Decline of Lung Function Antioxidants 9(5),pp.387 (Collaboration) 
4. 2020/04 Article Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases Biochemical and Biophysical Research Communications 524(2),pp.332-339 (Collaboration) 
5. 2020/01 Article Azithromycin inhibits constitutive airway epithelial sodium channel activation in vitro and modulates downstream pathogenesis in vivo Biological and Pharmaceutical Bulletin 43(4),pp.725-730 (Collaboration) 
Display all(17)
■ Academic conference presentation
1. 2017/02 Poly(I:C)-dependent anti-inflammatory IL-37b-SIGIRR negative feedback loop is defective in cystic fibrosis airway epithelial cells (15th Cytokines & Inflammation)
2. 2013/09 Lipopolysaccharide decreases SIGIRR expression by suppressing Sp1 via TLR4-p38 MAP kinase pathway in monocytes and neutrophils (Cytokines 2013)
3. 2013/09 Increased IL-17C production by TLR3 Ligand Poly(I:C) in Primary Cystic Fibrosis Airway Epithelial Cells (Cytokines 2013)
■ Academic background
1. 2000/04~2004/03 Faculty of Pharmaceutical Science, Kumamoto University, Graduated,
2. 2004/04~2006/03 〔Master Course〕, Graduate School, Division of Pharmaceutical Sciences, Kumamoto University, Completed,
3. 2006/04~2009/03 〔Doctorial Course〕, Graduate School, Division of Pharmaceutical Sciences, Kumamoto University, Completed,
■ Business career
1. 2008/04~2010/03 SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2. 2010/04~2018/03 SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
■ researchmap Researcher code
B000346847
■ Research topic, funded research, and department laboratory expense
1. 2019/04~2021/03  Elucidation of the regulation mechanism of cystic fibrosis-specific splice variant expression and development of novel therapeutic strategies  (Key Word : )
2. 2016/04~2019/03  Therapeutic application to cystic fibrosis based on IL-37 and stabilized cell surface expression of SIGIRR  (Key Word : )
3. 2014/04~2016/03  Molecular basis of SIGIRR expression and regulatory function in Cystic Fibrosis and its therapeutic approach  (Key Word : )
■ E-Mail Address
  kyoin_mail
■ Present specialized field
Biological pharmacy 
■ Department laboratory expense researcher number
70510692
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