Faculty Information - Shuto Keiko

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Book and thesis

Academic conference presentation

Academic background

Business career

researchmap Researcher code

Research topic, funded research, and department laboratory expense

E-Mail Address

Present specialized field

Department laboratory expense researcher number

（Last updated : 2022-12-14 14:27:19）

Shuto Keiko
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES

Position

■ Book and thesis

1.	2022/07	Article	A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells International Journal of Molecular Sciences 23(14),pp.7743 (Collaboration)
2.	2022/06	Article	Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases Journal of Pharmacological Sciences 149(2),pp.37-45 (Collaboration)
3.	2020/05	Article	Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor Against Pathophysiological Decline of Lung Function Antioxidants 9(5),pp.387 (Collaboration)
4.	2020/04	Article	Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases Biochemical and Biophysical Research Communications 524(2),pp.332-339 (Collaboration)
5.	2020/01	Article	Azithromycin inhibits constitutive airway epithelial sodium channel activation in vitro and modulates downstream pathogenesis in vivo Biological and Pharmaceutical Bulletin 43(4),pp.725-730 (Collaboration)
6.	2019/03	Article	Curcumin down-regulates toll-like receptor-2 gene expression and function in human cystic fibrosis bronchial epithelial cells Biological and Pharmaceutical Bulletin 42(3),pp.489-495 (Collaboration)
7.	2019/02	Article	Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation. Biochemical and Biophysical Research Communications 509(2),pp.521-528 (Collaboration)
8.	2018/11	Other	Smoking Status Among Pharmacy Students and the Environment that They Started Smoking Journal of Kyushu Pharmacy pp.7-11 (Collaboration)
9.	2018/01	Article	CFTR and ENaC controls cystic fibrosis-associated mucus hypersecretory phenotype through a novel splice switch of zinc importer ZIP2/SLC39A2 EBioMedicine 27,pp.304-316 (Collaboration)
10.	2014/06	Article	Lipopolysaccharide Decreases Single Immunoglobulin Interleukin-1Receptor-Related Molecule (SIGIRR) Expression by Suppressing Sp1 via TLR4-p38 pathway in monocytes and neutrophils Journal of Biological Chemistry 289(26),pp.18097-18109 (Collaboration)
11.	2013/09	Article	Increased IL-17C production by the TLR3 ligand poly(I:C) in primary cystic fibrosis airway epithelial cells Pediatric Pulmonology (Collaboration)
12.	2012/04	Article	Synergism between Interleukin-17 and Toll-like receptor 2 and 4 Signals to Induce IL-8 Expression in Cystic Fibrosis Airway Epithelial Cells Journal of Pharmacological Sciences 118(4),pp.512-520 (Collaboration)
13.	2009/11	Article	Calreticulin positively regulates the expression and function of epithelial sodium channel Experimental Cell Research 315(19),pp.3294-3300 (Collaboration)
14.	2008/03	Article	MUC1 mucin is a negative regulator of toll-like receotor signaling Americal Journal of Respiratory Cell and Molecular Biology 38,pp.263-268 (Collaboration)
15.	2008/01	Article	Phosphatidic acid metabolism regulates the intracellular trafficking and retrotranslocation of CFTR Biochimica et Biophysica Acta 1783,pp.153-162 (Collaboration)
16.	2006/05	Article	Calreticulin negatively regulates the cell surface expression of cystic fibrosis transmembrane conductance regulator Journal of Biological Chemistry 281,pp.12841-12848 (Collaboration)
17.	2004/08	Article	Characterization of the trafficking pathway of cystic fibrosis transmembrane conductance regulator in baby hamster kidney cells Journal of Pharmacological Sciences 95(4),pp.471-475 (Collaboration)
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■ Academic conference presentation

1.	2017/02	Poly(I:C)-dependent anti-inflammatory IL-37b-SIGIRR negative feedback loop is defective in cystic fibrosis airway epithelial cells (15th Cytokines & Inflammation)
2.	2013/09	Lipopolysaccharide decreases SIGIRR expression by suppressing Sp1 via TLR4-p38 MAP kinase pathway in monocytes and neutrophils (Cytokines 2013)
3.	2013/09	Increased IL-17C production by TLR3 Ligand Poly(I:C) in Primary Cystic Fibrosis Airway Epithelial Cells (Cytokines 2013)

■ Academic background

1.	2000/04～2004/03	Faculty of Pharmaceutical Science, Kumamoto University, Graduated,
2.	2004/04～2006/03	〔Master Course〕, Graduate School, Division of Pharmaceutical Sciences, Kumamoto University, Completed,
3.	2006/04～2009/03	〔Doctorial Course〕, Graduate School, Division of Pharmaceutical Sciences, Kumamoto University, Completed,

■ Business career

1.	2008/04～2010/03	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2.	2010/04～2018/03	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

■ researchmap Researcher code

B000346847

■ Research topic, funded research, and department laboratory expense

1.	2019/04～2021/03	Elucidation of the regulation mechanism of cystic fibrosis-specific splice variant expression and development of novel therapeutic strategies (Key Word : )
2.	2016/04～2019/03	Therapeutic application to cystic fibrosis based on IL-37 and stabilized cell surface expression of SIGIRR (Key Word : )
3.	2014/04～2016/03	Molecular basis of SIGIRR expression and regulatory function in Cystic Fibrosis and its therapeutic approach (Key Word : )

■ E-Mail Address

■ Present specialized field

Biological pharmacy

■ Department laboratory expense researcher number

70510692

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